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    spop speckle type BTB/POZ protein [ Danio rerio (zebrafish) ]

    Gene ID: 100005514, updated on 2-Nov-2024

    Summary

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    Official Symbol
    spopprovided by ZNC
    Official Full Name
    speckle type BTB/POZ proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1378
    See related
    Ensembl:ENSDARG00000100519 AllianceGenome:ZFIN:ZDB-GENE-040426-1378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SPOP1; zgc:64140
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in nuclear speck. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See spop in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (20657843..20793660, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (20508463..20571322, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene nerve growth factor receptor a (TNFR superfamily, member 16) Neighboring gene uncharacterized LOC103910239 Neighboring gene neurexophilin-1 Neighboring gene uncharacterized LOC137490535 Neighboring gene uncharacterized LOC137490537 Neighboring gene NDUFA4 mitochondrial complex associated a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SPOP mutation leads to genomic instability in prostate cancer. Boysen G, et al. Elife, 2015 Sep 16. PMID 26374986, Free PMC Article
    2. Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway. Yu GQ, et al. Int J Biol Macromol, 2024 Jan. PMID 38029910
    3. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Zhang Q, et al. Dev Cell, 2006 Jun. PMID 16740475
    4. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
    5. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64140, MGC174052

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    speckle-type POZ protein
    Names
    HIB homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201130.2 → NP_957424.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_957424.1

      Status: VALIDATED

      Source sequence(s)
      AL929247, BX248239, BX908767, CU855817
      UniProtKB/Swiss-Prot
      Q7T330
      UniProtKB/TrEMBL
      A7YYH8
      Related
      ENSDARP00000130146.1, ENSDART00000163473.2
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
      cl38908
      Location:179 → 301
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      20657843..20793660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215324.1 → XP_068071425.1  speckle-type POZ protein isoform X1

      Related
      ENSDARP00000152225.1, ENSDART00000193532.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T330.1 GenPept UniProtKB/Swiss-Prot:Q7T330

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.