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    alg1 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 334161, updated on 2-Nov-2024

    Summary

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    Official Symbol
    alg1provided by ZNC
    Official Full Name
    ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6093
    See related
    Ensembl:ENSDARG00000054963 AllianceGenome:ZFIN:ZDB-GENE-030131-6093
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66221; wu:fi34b12
    Summary
    Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See alg1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (28860292..28869640)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (28729450..28738798)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 70 Neighboring gene si:ch211-76l23.7 Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase Neighboring gene uncharacterized LOC101885742 Neighboring gene lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chitobiosyldiphosphodolichol beta-mannosyltransferase
    Names
    asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
    NP_956161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199867.1 → NP_956161.1  chitobiosyldiphosphodolichol beta-mannosyltransferase

      See identical proteins and their annotated locations for NP_956161.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055554
      UniProtKB/TrEMBL
      Q7SXK9
      Related
      ENSDARP00000071703.4, ENSDART00000077235.5
      Conserved Domains (2) summary
      cd03816
      Location:53 → 483
      GT1_ALG1_like; This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and ...
      PLN02275
      Location:57 → 446
      PLN02275; transferase, transferring glycosyl groups

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      28860292..28869640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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