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    snx10a sorting nexin 10a [ Danio rerio (zebrafish) ]

    Gene ID: 403027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx10aprovided by ZNC
    Official Full Name
    sorting nexin 10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-44
    See related
    Ensembl:ENSDARG00000004405 AllianceGenome:ZFIN:ZDB-GENE-050809-44
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Snx10; im:7153949
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Involved in Kupffer's vesicle development; cilium assembly; and left/right axis specification. Acts upstream of or within heart looping. Predicted to be located in cytoskeleton and endosome membrane. Predicted to be active in endosome. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See snx10a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (18118359..18130463, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (18655506..18664778, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene pyroglutamylated RFamide peptide Neighboring gene integrator complex subunit 8 Neighboring gene uncharacterized LOC103911055 Neighboring gene chromobox homolog 3a (HP1 gamma homolog, Drosophila)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Chen Y, et al. Cell Res, 2012 Feb. PMID 21844891, Free PMC Article
    2. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Hegedus Z, et al. Mol Immunol, 2009 Sep. PMID 19631987
    3. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
    4. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
    5. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-10A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139462.1 → NP_001132934.1  sorting nexin-10A

      See identical proteins and their annotated locations for NP_001132934.1

      Status: VALIDATED

      Source sequence(s)
      BC055622, BM184815, EH537271
      UniProtKB/Swiss-Prot
      F1Q506, Q7SXF9
      UniProtKB/TrEMBL
      A0A8M9P1S3
      Related
      ENSDARP00000098673.2, ENSDART00000108627.5
      Conserved Domains (1) summary
      cd06898
      Location:13 → 125
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      18118359..18130463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468032.2 → XP_021323707.1  sorting nexin-10A isoform X1

      UniProtKB/Swiss-Prot
      F1Q506, Q7SXF9
      UniProtKB/TrEMBL
      A0A8M9P1S3
      Related
      ENSDARP00000025688.7, ENSDART00000022803.8
      Conserved Domains (1) summary
      cd06898
      Location:13 → 125
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1Q506.1 GenPept UniProtKB/Swiss-Prot:F1Q506

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.