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    prkacbb protein kinase, cAMP-dependent, catalytic, beta b [ Danio rerio (zebrafish) ]

    Gene ID: 563147, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prkacbbprovided by ZNC
    Official Full Name
    protein kinase, cAMP-dependent, catalytic, beta bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050904-4
    See related
    Ensembl:ENSDARG00000059125 AllianceGenome:ZFIN:ZDB-GENE-050904-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prkacb; wu:fz54b03; zgc:110804; si:ch1073-339l18.1
    Summary
    Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in brain; fin bud; otic vesicle; and retina. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prkacbb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (1597739..1622651, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (2512455..2539187, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene complement component 8, beta polypeptide Neighboring gene DAB adaptor protein 1b Neighboring gene uncharacterized LOC137487641 Neighboring gene si:ch1073-339l18.2 Neighboring gene uncharacterized LOC110437908

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental expression patterns of protein kinase A catalytic subunits in zebrafish. Emerson SE, et al. Gene Expr Patterns, 2019 Jan. PMID 30468770
    2. Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Xu H, et al. Front Cell Dev Biol, 2022. PMID 35646941, Free PMC Article
    3. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
    4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC110804

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase, cAMP-dependent, catalytic, beta b
    NP_001030148.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034976.1 → NP_001030148.1  protein kinase, cAMP-dependent, catalytic, beta b

      See identical proteins and their annotated locations for NP_001030148.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103487
      UniProtKB/TrEMBL
      A0A8M1N7R8, A0A8M2BIA6, Q3ZB92
      Related
      ENSDARP00000076580.3, ENSDART00000082143.6
      Conserved Domains (2) summary
      PTZ00263
      Location:32 → 351
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:42 → 331
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      1597739..1622651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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