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    arid2 AT-rich interactive domain 2 [ Danio rerio (zebrafish) ]

    Gene ID: 566352, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arid2provided by ZNC
    Official Full Name
    AT-rich interactive domain 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6311
    See related
    Ensembl:ENSDARG00000007413 AllianceGenome:ZFIN:ZDB-GENE-030131-6311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi45a01; wu:fi45a01; zgc:152901; si:ch211-132p20.1
    Summary
    Predicted to enable DNA binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arid2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (1647096..1684400, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (1798174..1835451, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38 member 2 Neighboring gene SR-related CTD-associated factor 11 Neighboring gene growth arrest-specific 2 like 3 Neighboring gene FGFR1 oncogene partner 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SWI/SNF superfamily-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AT-rich interactive domain-containing protein 2
    Names
    AT rich interactive domain 2 (ARID, RFX-like)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077763.1 → NP_001071231.1  AT-rich interactive domain-containing protein 2

      See identical proteins and their annotated locations for NP_001071231.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127385
      UniProtKB/TrEMBL
      A0JPE6
      Related
      ENSDARP00000099617.4, ENSDART00000113360.4
      Conserved Domains (2) summary
      pfam01388
      Location:19 → 101
      ARID; ARID/BRIGHT DNA binding domain
      pfam02257
      Location:519 → 599
      RFX_DNA_binding; RFX DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      1647096..1684400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164457.5 → XP_005164514.1  AT-rich interactive domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBU2, F6NXG0
      Related
      ENSDARP00000011701.8, ENSDART00000019144.10
      Conserved Domains (2) summary
      pfam01388
      Location:19 → 101
      ARID; ARID/BRIGHT DNA binding domain
      pfam02257
      Location:519 → 599
      RFX_DNA_binding; RFX DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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