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    adgra3 adhesion G protein-coupled receptor A3 [ Danio rerio (zebrafish) ]

    Gene ID: 100003592, updated on 2-Nov-2024

    Summary

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    Official Symbol
    adgra3provided by ZNC
    Official Full Name
    adhesion G protein-coupled receptor A3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131003-2
    See related
    AllianceGenome:ZFIN:ZDB-GENE-131003-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gpr125
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within several processes, including Wnt signaling pathway, planar cell polarity pathway; motor neuron migration; and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Is expressed in several structures, including brain; liver; otic vesicle; pectoral fin; and pleuroperitoneal region. Orthologous to human ADGRA3 (adhesion G protein-coupled receptor A3). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See adgra3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (70267090..70333181, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (69816793..69882884, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene potassium voltage-gated channel interacting protein 4a Neighboring gene adhesion G protein-coupled receptor A3-like Neighboring gene glucosidase, beta, acid 3 (gene/pseudogene) Neighboring gene peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Li X, et al. Development, 2013 Jul. PMID 23821037, Free PMC Article
    2. Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Vanhollebeke B, et al. Elife, 2015 Jun 8. PMID 26051822, Free PMC Article
    3. Expression of the adhesion G protein-coupled receptor A2 (adgra2) during Xenopus laevis development. Seigfried FA, et al. Gene Expr Patterns, 2018 Jun. PMID 29462671
    4. A molecular mechanism for Wnt ligand-specific signaling. Eubelen M, et al. Science, 2018 Aug 17. PMID 30026314
    5. Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. Harty BL, et al. BMC Genomics, 2015 Feb 8. PMID 25715737, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Wnt signaling pathway, planar cell polarity pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Wnt signaling pathway, planar cell polarity pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor A3
    Names
    G-protein coupled receptor 125

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302224.1 → NP_001289153.1  adhesion G protein-coupled receptor A3 precursor

      See identical proteins and their annotated locations for NP_001289153.1

      Status: PROVISIONAL

      Source sequence(s)
      KC996731
      UniProtKB/Swiss-Prot
      S4X0Q8
      Conserved Domains (10) summary
      smart00082
      Location:176 → 223
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:236 → 328
      IG_like; Immunoglobulin like
      cd00116
      Location:73 → 162
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:70 → 93
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:680 → 721
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:350 → 403
      HRM; Hormone receptor domain
      pfam13855
      Location:92 → 152
      LRR_8; Leucine rich repeat
      pfam16489
      Location:424 → 648
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl11960
      Location:241 → 324
      Ig; Immunoglobulin domain
      cl21561
      Location:774 → 923
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      70267090..70333181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    S4X0Q8.1 GenPept UniProtKB/Swiss-Prot:S4X0Q8

    Gene LinkOut

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