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    pemt phosphatidylethanolamine N-methyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 393127, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pemtprovided by ZNC
    Official Full Name
    phosphatidylethanolamine N-methyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-719
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040426-719
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55479
    Summary
    Predicted to enable phosphatidylethanolamine N-methyltransferase activity. Predicted to be involved in phosphatidylcholine biosynthetic process. Predicted to act upstream of or within methylation and phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See pemt in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (1286531..1388444)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (1286973..1360126)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene lipase maturation factor 1 Neighboring gene ras-related protein Rab-26 Neighboring gene autotaxin-like Neighboring gene peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like Neighboring gene ras association domain-containing protein 4-like Neighboring gene uncharacterized LOC100535225 Neighboring gene uncharacterized LOC137496782 Neighboring gene uncharacterized LOC795264 Neighboring gene RAS, dexamethasone-induced 1 Neighboring gene mediator complex subunit 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio). Watt AT, et al. J Nutr Biochem, 2021 Nov. PMID 34119630, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55479

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidyl-N-methylethanolamine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylethanolamine N-methyltransferase
    NP_956452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200158.1 → NP_956452.1  phosphatidylethanolamine N-methyltransferase

      See identical proteins and their annotated locations for NP_956452.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045355
      UniProtKB/TrEMBL
      Q7ZVZ2
      Conserved Domains (1) summary
      pfam04191
      Location:121 → 223
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      1286531..1388444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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