znf423 zinc finger protein 423 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: znf423provided by ZNC
Official Full Name: zinc finger protein 423provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4368
See related: Ensembl:ENSDARG00000059707 AllianceGenome:ZFIN:ZDB-GENE-030131-4368
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc95d03; zgc:158272; si:ch211-212o1.3; si:ch211-216l23.1
Summary: Predicted to enable chromatin insulator sequence binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in nucleus. Predicted to be active in chromosome. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (17786028..17995064)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (17796904..18005998)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd09g07.y1 (e-PCR)
- UniSTS:195081

G44946 (e-PCR)
- UniSTS:105748

G47817 (e-PCR)
- UniSTS:108586

G47304 (e-PCR)
- UniSTS:108085

G47077 (e-PCR)
- UniSTS:107867

G40061 (e-PCR)
- UniSTS:32611

z99085 (e-PCR), detects polymorphism
- UniSTS:238486

G40946 (e-PCR)
- UniSTS:75170

G45878 (e-PCR)
- UniSTS:106680

fc95d03.x1 (e-PCR)
- UniSTS:204018

G39088 (e-PCR)
- UniSTS:40184

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin insulator sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 423

Names: zinc finger protein 423-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080030.1 → NP_001073499.1 zinc finger protein 423

See identical proteins and their annotated locations for NP_001073499.1

Status: PROVISIONAL

Source sequence(s)

BC129184

UniProtKB/Swiss-Prot

A1L1R6, Q1L943, Q1LX66

Related

ENSDARP00000146416.1, ENSDART00000189493.1

Conserved Domains (2) summary

COG5048
Location:151 → 256

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:152 → 172

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

17786028..17995064

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159129.5 → XP_005159186.1 zinc finger protein 423 isoform X1

UniProtKB/TrEMBL

A0A2U3TVM2, A0A8M2B5L6

Related

ENSDARP00000077731.4, ENSDART00000083296.6

Conserved Domains (2) summary

COG5048
Location:151 → 256

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:152 → 172

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_005159130.5 → XP_005159187.1 zinc finger protein 423 isoform X2

UniProtKB/TrEMBL

A0A2R8PYF9, A0A8M2B639

Related

ENSDARP00000144947.1, ENSDART00000187095.1

Conserved Domains (2) summary

COG5048
Location:131 → 236

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:132 → 152

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_068214810.1 → XP_068070911.1 zinc finger protein 423 isoform X3