msrb1a methionine sulfoxide reductase B1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: msrb1aprovided by ZNC
Official Full Name: methionine sulfoxide reductase B1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030411-3
See related: Ensembl:ENSDARG00000025436 AllianceGenome:ZFIN:ZDB-GENE-030411-3
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MsrB; SePR; selx; cb687; sepx1; SelX-A; sepx1a; MsrB1-A; wu:fa03e09
Summary: The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A paralog of this gene (msrb1b) exists on chromosome 12. [provided by RefSeq, Oct 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (18798431..18805297, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (18649165..18655540, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj82b03.x1 (e-PCR)
- UniSTS:200014

fa03e09.s1 (e-PCR)
- UniSTS:202171

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-methionine-(R)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (R)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-methionine (R)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (R)-S-oxide reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein repair	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methionine-R-sulfoxide reductase B1-A

Names: methionine-R-sulfoxide reductase B1; msrB1; selenoprotein X, 1; selenoprotein X, 1a; selenoprotein X-A

NP_840073.2

EC 1.8.4.12

EC 1.8.4.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.