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    hyou1 hypoxia up-regulated 1 [ Danio rerio (zebrafish) ]

    Gene ID: 327133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hyou1provided by ZNC
    Official Full Name
    hypoxia up-regulated 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5344
    See related
    Ensembl:ENSDARG00000013670 AllianceGenome:ZFIN:ZDB-GENE-030131-5344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56019; id:ibd5056; wu:fd14c05
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including anterior axial hypoblast; digestive system; hatching gland; immature eye; and polster. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hyou1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (29770231..29791466)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (29883891..29905126)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 46 homolog (Chlamydomonas) Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene si:ch73-261i21.5 Neighboring gene histone 2, H2, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation. Crawford KC, et al. Genesis, 2011 Dec. PMID 21557452
    2. Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach. Ma D, et al. J Proteome Res, 2018 Mar 2. PMID 29369637
    3. Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Lui EY, et al. J Genet Genomics, 2016 Aug 20. PMID 27503704
    4. Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish. Delaney P, et al. Toxicol Appl Pharmacol, 2020 Dec 15. PMID 33147493, Free PMC Article
    5. Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Xu K, et al. Genes (Basel), 2018 Nov 29. PMID 30501106, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hypoxia up-regulated protein 1
    Names
    oxygen regulated protein (150kD)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212703.1 → NP_997868.1  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_997868.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047807
      UniProtKB/Swiss-Prot
      Q6IQN2, Q7ZUW2
      UniProtKB/TrEMBL
      B2GRZ4
      Related
      ENSDARP00000090804.4, ENSDART00000100032.5
      Conserved Domains (3) summary
      cd10230
      Location:28 → 414
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:27 → 705
      HSP70; Hsp70 protein
      pfam15713
      Location:598 → 648
      PTPRCAP; Protein tyrosine phosphatase receptor type C-associated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      29770231..29791466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUW2.1 GenPept UniProtKB/Swiss-Prot:Q7ZUW2

    Gene LinkOut

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