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    mecr mitochondrial trans-2-enoyl-CoA reductase [ Danio rerio (zebrafish) ]

    Gene ID: 550550, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mecrprovided by ZNC
    Official Full Name
    mitochondrial trans-2-enoyl-CoA reductaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-399
    See related
    Ensembl:ENSDARG00000032326 AllianceGenome:ZFIN:ZDB-GENE-050417-399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110153
    Summary
    Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mecr in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4695086..4707671)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (4864875..4878382)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily T, polypeptide 8 Neighboring gene lin-28 homolog Aa Neighboring gene sphingomyelin phosphodiesterase acid like 3B Neighboring gene thymocyte selection associated family member 2 Neighboring gene replication protein A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enoyl-[acyl-carrier-protein] reductase, mitochondrial
    Names
    2-enoyl thioester reductase
    trans-2-enoyl-CoA reductase, mitochondrial
    NP_001017852.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017852.1 → NP_001017852.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001017852.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092759
      UniProtKB/Swiss-Prot
      Q6GQN8
      UniProtKB/TrEMBL
      Q568Q9
      Related
      ENSDARP00000038801.6, ENSDART00000039054.8
      Conserved Domains (2) summary
      cd08290
      Location:45 → 377
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:46 → 366
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      4695086..4707671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQN8.2 GenPept UniProtKB/Swiss-Prot:Q6GQN8

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