suz12a SUZ12 polycomb repressive complex 2 subunit a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: suz12aprovided by ZNC
Official Full Name: SUZ12 polycomb repressive complex 2 subunit aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-36
See related: Ensembl:ENSDARG00000070256 AllianceGenome:ZFIN:ZDB-GENE-040801-36
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: suz12; suz12l; zgc:100863
Summary: Predicted to enable chromatin DNA binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be part of ESC/E(Z) complex and RSC-type complex. Predicted to be active in nucleus. Is expressed in gonad; midbrain hindbrain boundary; pharyngeal arch; and visual system. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (35849672..35865025, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (35721299..35735272, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.
Title: suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RSC-type complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polycomb protein suz12-A

Names: SUZ12 polycomb repressive complex 2a subunit; suppressor of zeste 12 homolog a; suppressor of zeste 12 homolog, like; suppressor of zeste 12 protein homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003529.2 → NP_001003529.1 polycomb protein suz12-A

See identical proteins and their annotated locations for NP_001003529.1

Status: PROVISIONAL

Source sequence(s)

BC078293

UniProtKB/Swiss-Prot

A7YYE1, Q6DC03

Related

ENSDARP00000093727.4, ENSDART00000102952.5

Conserved Domains (1) summary

pfam09733
Location:511 → 645

VEFS-Box; VEFS-Box of polycomb protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

35849672..35865025 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471664.2 → XP_021327339.1 polycomb protein suz12-A isoform X1

UniProtKB/TrEMBL

A0A8M9PR46

Conserved Domains (1) summary

pfam09733
Location:511 → 644

VEFS-Box; VEFS-Box of polycomb protein