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    abcd4 ATP-binding cassette, sub-family D (ALD), member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 767748, updated on 2-Nov-2024

    Summary

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    Official Symbol
    abcd4provided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family D (ALD), member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050517-30
    See related
    Ensembl:ENSDARG00000061770 AllianceGenome:ZFIN:ZDB-GENE-050517-30
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153503
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in endoderm; head; intermediate cell mass of mesoderm; muscle; and pronephric duct. Used to study vitamin B12 deficiency. Orthologous to human ABCD4 (ATP binding cassette subfamily D member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See abcd4 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (35910962..35930395)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (36022864..36042221)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 178 Neighboring gene kelch-like family member 14 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b Neighboring gene guanine nucleotide-binding protein G(s) subunit alpha Neighboring gene im:7140347

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of abcd4 in zebrafish leads to vitamin B(12)-deficiency anemia. Choi YM, et al. Biochem Biophys Res Commun, 2019 Jul 5. PMID 31113616
    2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
    3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
    4. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
    5. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153503

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal cobalamin transporter ABCD4
    NP_001070185.2
    XP_005162924.1
    XP_021325897.1
    XP_068073222.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076717.2 → NP_001070185.2  lysosomal cobalamin transporter ABCD4

      Status: VALIDATED

      Source sequence(s)
      BX293567, CR792456
      UniProtKB/TrEMBL
      A0A8M1NB84, F1Q4Y1
      Related
      ENSDARP00000110201.2, ENSDART00000129679.3
      Conserved Domains (3) summary
      cd03223
      Location:385 → 596
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG4178
      Location:18 → 603
      YddA; ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]
      cl00549
      Location:14 → 292
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      35910962..35930395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470222.2 → XP_021325897.1  lysosomal cobalamin transporter ABCD4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P5Z5
      Conserved Domains (1) summary
      COG4178
      Location:18 → 589
      YddA; ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]

    2. XM_005162867.5 → XP_005162924.1  lysosomal cobalamin transporter ABCD4 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B9T8
      Conserved Domains (3) summary
      cd03223
      Location:231 → 442
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG4133
      Location:244 → 436
      CcmA; ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:1 → 138
      ABC_membrane; ABC transporter transmembrane region

    3. XM_068217121.1 → XP_068073222.1  lysosomal cobalamin transporter ABCD4 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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