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    meis1a Meis homeobox 1 a [ Danio rerio (zebrafish) ]

    Gene ID: 170455, updated on 14-Nov-2024

    Summary

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    Official Symbol
    meis1aprovided by ZNC
    Official Full Name
    Meis homeobox 1 aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020122-3
    See related
    Ensembl:ENSDARG00000002937 AllianceGenome:ZFIN:ZDB-GENE-020122-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    meis4.1a; meis4.1b
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; pectoral fin bud; pectoral fin musculature; and segmental plate. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See meis1a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (51479114..51525084)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (50835234..50881285)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2a Neighboring gene sprouty related EVH1 domain containing 2a Neighboring gene ETAA1 activator of ATR kinase a Neighboring gene protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. Schulte EC, et al. Am J Hum Genet, 2014 Jul 3. PMID 24995868, Free PMC Article
    2. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Amin S, et al. Dev Cell, 2015 Feb 9. PMID 25640223, Free PMC Article
    3. Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Pradhan SJ, et al. Nat Commun, 2021 Oct 19. PMID 34667153, Free PMC Article
    4. Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Xiao C, et al. Nat Commun, 2016 Dec 8. PMID 27929112, Free PMC Article
    5. Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Macaulay IC, et al. Cell Rep, 2016 Feb 2. PMID 26804912, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis1a
    Names
    myeloid ecotropic viral integration site 4.1a
    myeloid ecotropic viral integration site 4.1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131897.2 → NP_571972.2  homeobox protein Meis1a

      See identical proteins and their annotated locations for NP_571972.2

      Status: PROVISIONAL

      Source sequence(s)
      BC056317
      UniProtKB/TrEMBL
      A0A8M1PCH5, Q7SZP3
      Related
      ENSDARP00000026780.9, ENSDART00000028018.11
      Conserved Domains (2) summary
      pfam05920
      Location:279 → 318
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 182
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      51479114..51525084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160124.5 → XP_005160181.1  homeobox protein Meis1a isoform X1

      See identical proteins and their annotated locations for XP_005160181.1

      UniProtKB/TrEMBL
      A0A8M1PCH5, Q7SZP3
      Conserved Domains (2) summary
      pfam05920
      Location:279 → 318
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 182
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_005160125.4 → XP_005160182.1  homeobox protein Meis1a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7B4
      Conserved Domains (2) summary
      pfam05920
      Location:279 → 318
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 182
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein
    Heading Accession and Version

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