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    tysnd1 trypsin like peroxisomal matrix peptidase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 561667, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tysnd1provided by ZNC
    Official Full Name
    trypsin like peroxisomal matrix peptidase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8525
    See related
    Ensembl:ENSDARG00000074895 AllianceGenome:ZFIN:ZDB-GENE-030131-8525
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb14b12
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing and regulation of fatty acid beta-oxidation. Predicted to act upstream of or within proteolysis. Predicted to be active in peroxisome. Orthologous to human TYSND1 (trypsin like peroxisomal matrix peptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tysnd1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (30122107..30142094, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (30005396..30011637, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B12a Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene secretion associated, Ras related GTPase 1Ab Neighboring gene inorganic pyrophosphatase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal leader peptide-processing protease
    Names
    trypsin domain containing 1
    NP_001122182.1
    XP_068068973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128710.1 → NP_001122182.1  peroxisomal leader peptide-processing protease

      See identical proteins and their annotated locations for NP_001122182.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162169
      UniProtKB/TrEMBL
      A0A8M9Q9R7, B3DFU6
      Related
      ENSDARP00000097678.1, ENSDART00000110157.3
      Conserved Domains (2) summary
      pfam13365
      Location:317 → 456
      Trypsin_2; Trypsin-like peptidase domain
      cl28339
      Location:145 → 242
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      30122107..30142094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212872.1 → XP_068068973.1  peroxisomal leader peptide-processing protease isoform X1

    Nucleotide Protein
    Heading Accession and Version

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