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    svild supervillin d [ Danio rerio (zebrafish) ]

    Gene ID: 562786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    svildprovided by ZNC
    Official Full Name
    supervillin dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-483
    See related
    Ensembl:ENSDARG00000102056 AllianceGenome:ZFIN:ZDB-GENE-081104-483
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-94b4.1
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in macula. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See svild in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (15690416..15823368)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (15648079..15780649)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 3b Neighboring gene N-myristoyltransferase 1b Neighboring gene uncharacterized LOC108191706 Neighboring gene uncharacterized LOC101885952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. Pollock LM, et al. PLoS One, 2016. PMID 27415442, Free PMC Article
    2. Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. England SJ, et al. Neural Dev, 2023 Nov 28. PMID 38017520, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    supervillin; uncharacterized protein LOC562786

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      15690416..15823368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306541.4 → XP_009304816.1  supervillin isoform X1

      UniProtKB/TrEMBL
      A0A8M3B4H9
      Conserved Domains (5) summary
      pfam09528
      Location:8 → 424
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd11289
      Location:686 → 782
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1004 → 1110
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1426 → 1460
      VHP; Villin headpiece domain
      cl15697
      Location:806 → 882
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. XM_009306542.4 → XP_009304817.1  supervillin isoform X2

      UniProtKB/TrEMBL
      A0A0R4ICW1, A0A8M3AY87
      Related
      ENSDARP00000130945.1, ENSDART00000166803.3
      Conserved Domains (4) summary
      cd11289
      Location:686 → 782
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1003 → 1109
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1425 → 1459
      VHP; Villin headpiece domain
      cl15697
      Location:806 → 907
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    3. XM_021480277.2 → XP_021335952.1  supervillin isoform X3

      UniProtKB/TrEMBL
      A0A8M9PWX9
      Conserved Domains (4) summary
      cd11289
      Location:542 → 638
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:860 → 966
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1282 → 1316
      VHP; Villin headpiece domain
      cl15697
      Location:662 → 738
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein Strain
    Heading Accession and Version

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