kmo kynurenine 3-monooxygenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kmoprovided by ZNC
Official Full Name: kynurenine 3-monooxygenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030424-4
See related: Ensembl:ENSDARG00000009160 AllianceGenome:ZFIN:ZDB-GENE-030424-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb362; zgc:136684
Summary: Predicted to enable kynurenine 3-monooxygenase activity. Acts upstream of or within podocyte development and response to yeast. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in liver; pronephric duct; and pronephros. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (42272515..42306348, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003337164.1 (3550..9563)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes
Title: Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables kynurenine 3-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine 3-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables kynurenine 3-monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IEA Inferred from Electronic Annotation more info
involved_in NAD metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in anthranilate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in kynurenine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kynurenine 3-monooxygenase

NP_001314753.2

EC 1.14.13.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327824.2 → NP_001314753.2 kynurenine 3-monooxygenase

Status: VALIDATED

Source sequence(s)

BX005050

UniProtKB/TrEMBL

A0A8M1P332

Related

ENSDARP00000024051.6, ENSDART00000003706.8

Conserved Domains (1) summary

COG0654
Location:19 → 369

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]