U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    igfbp5b insulin-like growth factor binding protein 5b [ Danio rerio (zebrafish) ]

    Gene ID: 403039, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    igfbp5bprovided by ZNC
    Official Full Name
    insulin-like growth factor binding protein 5bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040319-2
    See related
    Ensembl:ENSDARG00000025348 AllianceGenome:ZFIN:ZDB-GENE-040319-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    igfbp5; igfbp5a
    Summary
    Predicted to enable fibronectin binding activity; insulin-like growth factor I binding activity; and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; gonad; median fin fold; otic vesicle; and pectoral fin bud. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See igfbp5b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (46820636..46842179, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (47020157..47041700, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch73-193i22.1 Neighboring gene insulin-like growth factor binding protein 2b Neighboring gene uncharacterized LOC137496411 Neighboring gene tensin 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two grass carp (Ctenopharyngodon idella) insulin-like growth factor-binding protein 5 genes exhibit different yet conserved functions in development and growth. Zheng GD, et al. Comp Biochem Physiol B Biochem Mol Biol, 2017 Feb. PMID 27913274
    2. Alteration of organ size and allometric scaling by organ-specific targeting of IGF signaling. Kamei H, et al. Gen Comp Endocrinol, 2021 Dec 1. PMID 34606746
    3. Phylogenetic analysis of the insulin-like growth factor binding protein (IGFBP) and IGFBP-related protein gene families. Rodgers BD, et al. Gen Comp Endocrinol, 2008 Jan 1. PMID 17537438, Free PMC Article
    4. The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition. Liu C, et al. Elife, 2020 Apr 16. PMID 32293560, Free PMC Article
    5. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Dai W, et al. Cell Death Differ, 2014 Apr. PMID 24336047, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    insulin-like growth factor-binding protein 5b
    Names
    insulin-like growth factor binding protein 5
    insulin-like growth factor binding protein 5a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126463.1 → NP_001119935.1  insulin-like growth factor-binding protein 5b precursor

      See identical proteins and their annotated locations for NP_001119935.1

      Status: PROVISIONAL

      Source sequence(s)
      BX005007
      UniProtKB/TrEMBL
      A0A8M1NJJ8, B0S525
      Related
      ENSDARP00000054136.6, ENSDART00000054137.8
      Conserved Domains (2) summary
      smart00121
      Location:21 → 97
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:183 → 254
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      46820636..46842179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools