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    sall2 spalt-like transcription factor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 568044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sall2provided by ZNC
    Official Full Name
    spalt-like transcription factor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-32
    See related
    Ensembl:ENSDARG00000075116 AllianceGenome:ZFIN:ZDB-GENE-030829-32
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc29e07; sb:cb763; wu:fc29e07; si:ch211-10e2.7
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; neural tube; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in coloboma. Orthologous to human SALL2 (spalt like transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sall2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (38147516..38156824)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (38166699..38174502)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene cerebellin 12 Neighboring gene tripartite motif containing 110 Neighboring gene matrix metallopeptidase 14b (membrane-inserted) Neighboring gene apoptotic chromatin condensation inducer 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Wan F, et al. Front Immunol, 2016. PMID 28119690, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sal-like protein 2; spalt-like transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      38147516..38156824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214383.1 → XP_068070484.1  sal-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YU75
      Related
      ENSDARP00000148781.1, ENSDART00000180948.1

    2. XM_021467769.2 → XP_021323444.1  sal-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YU75, A0A8M9PFQ7
      Conserved Domains (3) summary
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:404 → 429
      zf-H2C2_2; Zinc-finger double domain
      cl26305
      Location:838 → 1149
      XPG_I; XPG I-region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394506.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      192849..201969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218036.1 → XP_068074137.1  sal-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YU75
    Nucleotide Protein Strain
    Heading Accession and Version

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