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    cluha clustered mitochondria (cluA/CLU1) homolog a [ Danio rerio (zebrafish) ]

    Gene ID: 562666, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cluhaprovided by ZNC
    Official Full Name
    clustered mitochondria (cluA/CLU1) homolog aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061103-457
    See related
    Ensembl:ENSDARG00000030913 AllianceGenome:ZFIN:ZDB-GENE-061103-457
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cluh; cb498; sb:cb498; wu:fb77e08; wu:fd36f07; wu:fe05g06; wu:fi27b10; zgc:152873
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Predicted to be active in cytoplasm. Is expressed in several structures, including adaxial cell; eye; midbrain; musculature system; and pleuroperitoneal region. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cluha in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (25320107..25367247, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (25386309..25432022, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a Neighboring gene coiled-coil domain containing 92Ba Neighboring gene TLC domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary plasticity of segmentation clock networks. Krol AJ, et al. Development, 2011 Jul. PMID 21652651, Free PMC Article
    2. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    3. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0664

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular distribution of mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    clustered mitochondria protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077560.1 → NP_001071028.1  clustered mitochondria protein homolog

      See identical proteins and their annotated locations for NP_001071028.1

      Status: PROVISIONAL

      Source sequence(s)
      BC125829
      UniProtKB/Swiss-Prot
      A0JMD0, Q5CZT5
      Related
      ENSDARP00000047470.5, ENSDART00000047471.8
      Conserved Domains (6) summary
      sd00006
      Location:1172 → 1200
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:879 → 1058
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:401 → 621
      CLU; Clustered mitochondria
      pfam13374
      Location:1131 → 1170
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1210 → 1288
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:110 → 183
      CLU_N; Mitochondrial function, CLU-N-term

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      25320107..25367247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157586.5 → XP_005157643.1  clustered mitochondria protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4G7
      Conserved Domains (6) summary
      sd00006
      Location:1143 → 1171
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:850 → 1029
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:401 → 621
      CLU; Clustered mitochondria
      pfam13374
      Location:1102 → 1141
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1181 → 1259
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:110 → 183
      CLU_N; Mitochondrial function, CLU-N-term

    2. XM_005157587.5 → XP_005157644.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A8M2B4F2
      Conserved Domains (6) summary
      sd00006
      Location:1122 → 1150
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:829 → 1008
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:351 → 571
      CLU; Clustered mitochondria
      pfam13374
      Location:1081 → 1120
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1160 → 1238
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:60 → 133
      CLU_N; Mitochondrial function, CLU-N-term

    3. XM_021481439.2 → XP_021337114.1  clustered mitochondria protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M9QHB0
      Conserved Domains (5) summary
      sd00006
      Location:1172 → 1200
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:876 → 1058
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:401 → 621
      CLU; Clustered mitochondria
      pfam13424
      Location:1212 → 1288
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:110 → 183
      CLU_N; Mitochondrial function, CLU-N-term
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JMD0.1 GenPept UniProtKB/Swiss-Prot:A0JMD0

    Gene LinkOut

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