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    plg plasminogen [ Danio rerio (zebrafish) ]

    Gene ID: 322691, updated on 2-Nov-2024

    Summary

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    Official Symbol
    plgprovided by ZNC
    Official Full Name
    plasminogenprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1411
    See related
    Ensembl:ENSDARG00000023111 AllianceGenome:ZFIN:ZDB-GENE-030131-1411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb70e09
    Summary
    Predicted to enable endopeptidase activity and signaling receptor binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; conjunctivitis; hereditary angioedema; myocardial infarction; and plasminogen deficiency type I. Orthologous to several human genes including PLG (plasminogen). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plg in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (42688488..42702819, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (42791378..42805709, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 receptor Neighboring gene solute carrier family 22 member 2 Neighboring gene si:ch211-140l13.3 Neighboring gene uncharacterized LOC137488688 Neighboring gene G protein-coupled receptor 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish. Pontius MHH, et al. Proc Natl Acad Sci U S A, 2024 Mar 5. PMID 38408253, Free PMC Article
    2. Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors. Jendroszek A, et al. J Biol Chem, 2019 Mar 8. PMID 30651349, Free PMC Article
    3. Whole extracts of Radix Achyranthis Bidentatae and Radix Cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo. Zhou X, et al. Exp Ther Med, 2017 Mar. PMID 28450937, Free PMC Article
    4. An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Pereiro P, et al. Front Immunol, 2022. PMID 36713462, Free PMC Article
    5. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plasminogen
    NP_958880.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201472.2 → NP_958880.2  plasminogen precursor

      Status: VALIDATED

      Source sequence(s)
      AL845424
      UniProtKB/TrEMBL
      A0A8M1PG22, F1Q890
      Related
      ENSDARP00000045815.5, ENSDART00000045816.7
      Conserved Domains (4) summary
      smart00130
      Location:281 → 361
      KR; Kringle domain
      cd00190
      Location:589 → 813
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:31 → 104
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00051
      Location:376 → 453
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      42688488..42702819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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