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    sp5l Sp5 transcription factor-like [ Danio rerio (zebrafish) ]

    Gene ID: 324261, updated on 14-Nov-2024

    Summary

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    Official Symbol
    sp5lprovided by ZNC
    Official Full Name
    Sp5 transcription factor-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2981
    See related
    Ensembl:ENSDARG00000115868 AllianceGenome:ZFIN:ZDB-GENE-030131-2981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Spr2; cb577; YF-335; fc23b01; sb:cb577; wu:fc23b01
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesoderm formation; notochord development; and post-anal tail morphogenesis. Is expressed in several structures, including forerunner cell group; mesoderm; nervous system; neural plate; and notochord. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See sp5l in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28023087..28025851, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28096546..28099310, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 33Aa Neighboring gene Rho guanine nucleotide exchange factor (GEF) 25a Neighboring gene solute carrier family 26 member 10 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, like a Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling. Duncan RN, et al. Development, 2016 Jan 1. PMID 26603385, Free PMC Article
    2. Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation. Ishimatsu K, et al. Development, 2018 Jun 11. PMID 29769221, Free PMC Article
    3. More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Azbazdar Y, et al. Front Cell Dev Biol, 2019. PMID 31803740, Free PMC Article
    4. Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Lekven AC, et al. Dev Biol, 2003 Feb 15. PMID 12591239
    5. GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. Costa AM, et al. PLoS One, 2013. PMID 23840876, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sp5l mediates the functions of Fgf signals in anteroposterior patterning of the neuroectoderm during zebrafish embryogenesis.
      Title: Sp5l is a mediator of Fgf signals in anteroposterior patterning of the neuroectoderm in zebrafish embryo.
    2. sp5l is downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish.
      Title: Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish.
    3. sp5-like is a direct target of Wnt/beta-catenin signaling during gastrulation and, together with sp5, acts as a required mediator of the activities of wnt8 in patterning the mesoderm and neuroectoderm.
      Title: The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hindbrain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sp5 transcription factor-like
    Names
    SP1-like transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194371.2 → NP_919352.1  Sp5 transcription factor-like

      See identical proteins and their annotated locations for NP_919352.1

      Status: PROVISIONAL

      Source sequence(s)
      AY338748
      UniProtKB/TrEMBL
      Q6VMC5, Q7T2W1
      Related
      ENSDARP00000155656.1, ENSDART00000181146.1
      Conserved Domains (3) summary
      sd00017
      Location:255 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:280 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296 → 319
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      28023087..28025851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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