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    • Showing Current items.

    hells helicase, lymphoid specific [ Danio rerio (zebrafish) ]

    Gene ID: 553328, updated on 9-Dec-2024

    Summary

    Official Symbol
    hellsprovided by ZNC
    Official Full Name
    helicase, lymphoid specificprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9923
    See related
    Ensembl:ENSDARG00000057738 AllianceGenome:ZFIN:ZDB-GENE-030131-9923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb65; pasg; sb:cb65; sb:cb749; im:6911667
    Summary
    Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Acts upstream of or within chromosomal DNA methylation maintenance following DNA replication. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See hells in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (8255221..8270717)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (7923198..7938694)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene cGMP-dependent protein kinase 2 Neighboring gene si:ch211-250c4.3 Neighboring gene coiled-coil domain 110 molecular ruler complex subunit Neighboring gene atlastin GTPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleosome array spacer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037101.1NP_001032178.1  lymphoid-specific helicase

      See identical proteins and their annotated locations for NP_001032178.1

      Status: PROVISIONAL

      Source sequence(s)
      AY612850
      UniProtKB/TrEMBL
      Q3BDS6
      Related
      ENSDARP00000074914.2, ENSDART00000080465.3
      Conserved Domains (5) summary
      COG0513
      Location:605832
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00046
      Location:253395
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:236510
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:614728
      Helicase_C; Helicase conserved C-terminal domain
      pfam07557
      Location:518534
      Shugoshin_C; Shugoshin C terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      8255221..8270717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394863.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      283519..299015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395305.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      100228..115618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)