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    tpm4b tropomyosin 4b [ Danio rerio (zebrafish) ]

    Gene ID: 324244, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tpm4bprovided by ZNC
    Official Full Name
    tropomyosin 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2964
    See related
    Ensembl:ENSDARG00000019128 AllianceGenome:ZFIN:ZDB-GENE-030131-2964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmp4; zgc:63734; wu:fc22f09
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Predicted to be active in actin filament. Is expressed in cardiovascular system; cephalic musculature; epiphysis; and otic vesicle. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See tpm4b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (55300425..55335891, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (55567558..55603036, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 3 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene uncharacterized LOC137488274 Neighboring gene lipoprotein lipase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Dube DK, et al. Cytoskeleton (Hoboken), 2017 Mar. PMID 27998020, Free PMC Article
    2. CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Hofeichner J, et al. Sci Rep, 2023 Dec 19. PMID 38114601, Free PMC Article
    3. Cardiomyocyte heterogeneity during zebrafish development and regeneration. Tsedeke AT, et al. Dev Biol, 2021 Aug. PMID 33857482
    4. foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Whitesell TR, et al. Dev Biol, 2019 Sep 1. PMID 31199900
    5. The evolution of compositionally and functionally distinct actin filaments. Gunning PW, et al. J Cell Sci, 2015 Jun 1. PMID 25788699

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin 4b
    Names
    TPM4-2 alpha
    tropomyosin 4-2alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199675.2 → NP_955969.1  tropomyosin 4b

      See identical proteins and their annotated locations for NP_955969.1

      Status: VALIDATED

      Source sequence(s)
      AI444323, CU693474, CU693492
      UniProtKB/TrEMBL
      A0A8M1PFN8, Q7SXW1
      Related
      ENSDARP00000137812.1, ENSDART00000169382.2
      Conserved Domains (1) summary
      pfam00261
      Location:13 → 246
      Tropomyosin; Tropomyosin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      55300425..55335891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357672.3 → XP_017213161.1  tropomyosin 4b isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z082

    2. XM_017357674.3 → XP_017213163.1  tropomyosin 4b isoform X1

      UniProtKB/TrEMBL
      A0A1L6UW65
      Related
      ENSDARP00000143569.2, ENSDART00000177924.2
      Conserved Domains (2) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin
      pfam16526
      Location:13 → 72
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    Nucleotide Protein Strain
    Heading Accession and Version

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