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    dvl2 dishevelled segment polarity protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 323630, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dvl2provided by ZNC
    Official Full Name
    dishevelled segment polarity protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041118-20
    See related
    Ensembl:ENSDARG00000056184 AllianceGenome:ZFIN:ZDB-GENE-041118-20
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu471; zgc:55372; wu:fc05d12; wu:fo71e09; wu:fp54a02
    Summary
    Predicted to enable frizzled binding activity. Involved in convergent extension; non-canonical Wnt signaling pathway; and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within cell migration in hindbrain; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and vertebral column. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dvl2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (20260449..20293450)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (20008481..20041482)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch73-335l21.4 Neighboring gene si:ch73-335l21.2 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene zgc:194312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dishevelled2 is a stable protein during early zebrafish development. Lum WM, et al. Zebrafish, 2011 Jun. PMID 21663448
    2. Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Waxman JS, et al. Development, 2004 Dec. PMID 15539487
    3. Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Qi J, et al. J Biol Chem, 2017 Apr 7. PMID 28223363, Free PMC Article
    4. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Carvalho CM, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439725, Free PMC Article
    5. Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning. Shiomi K, et al. Curr Biol, 2003 Jan 8. PMID 12526749

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models.
      Title: A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models.
    2. Maternal transcripts for dvl2 and dvl3a are most abundantly expressed, whereas the transcript levels of other dvl genes are negligible. Dvl2 and Dvl3a products are required for the activation of zygotic Wnt/ss-catenin signaling and Wnt/planar cell polarity pathway, and regulate zygotic developmental processes in a dosage-dependent manner.
      Title: Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements.
    3. Dishevelled interacts with Lurap1 to regulate cellular polarisation during gastrulation.
      Title: Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.
    4. demonstrate that during early zebrafish development Nkd1 does not alter either endogenous or exogenous levels of Dvl2
      Title: Dishevelled2 is a stable protein during early zebrafish development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in convergent extension TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within head development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    segment polarity protein dishevelled homolog DVL-2
    Names
    dishevelled 2, dsh homolog
    dishevelled, dsh homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212648.1 → NP_997813.1  segment polarity protein dishevelled homolog DVL-2

      See identical proteins and their annotated locations for NP_997813.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044381
      UniProtKB/TrEMBL
      Q803Q5
      Related
      ENSDARP00000021237.8, ENSDART00000012450.11
      Conserved Domains (5) summary
      smart00021
      Location:1 → 82
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:251 → 338
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:408 → 491
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:112 → 249
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:498 → 737
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      20260449..20293450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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