U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    apoa4b.2 apolipoprotein A-IV b, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 570354, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apoa4b.2provided by ZNC
    Official Full Name
    apolipoprotein A-IV b, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3143
    See related
    Ensembl:ENSDARG00000020866 AllianceGenome:ZFIN:ZDB-GENE-030131-3143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc28d04; wu:fc10a03; wu:fc28d04; zgc:194131
    Summary
    Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in ball; extension; intestine; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See apoa4b.2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (23947197..23948538)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24032187..24033399)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-7f3.14 Neighboring gene apolipoprotein A-IV b, tandem duplicate 3 Neighboring gene apolipoprotein Eb Neighboring gene apolipoprotein C-I

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring. Skjærven KH, et al. Sci Rep, 2018 Feb 14. PMID 29445184, Free PMC Article
    2. Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding. Jawahar J, et al. BMC Genomics, 2022 Mar 22. PMID 35317738, Free PMC Article
    3. Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake. Otis JP, et al. Dis Model Mech, 2015 Mar. PMID 25633982, Free PMC Article
    4. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Jin C, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Nov. PMID 28888875
    5. Dhx15 regulates zebrafish intestinal development through the Wnt signaling pathway. Yao J, et al. Genomics, 2023 Mar. PMID 36775210

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    apolipoprotein A-IV b, tandem duplicate 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128758.1 → NP_001122230.1  apolipoprotein A-IV b, tandem duplicate 2 precursor

      See identical proteins and their annotated locations for NP_001122230.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162715
      UniProtKB/TrEMBL
      A0A8M9NZC6, B3DHC5, B3DHC6
      Related
      ENSDARP00000093966.3, ENSDART00000103190.5
      Conserved Domains (1) summary
      pfam01442
      Location:71 → 234
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      23947197..23948538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466733.1 → XP_021322408.1  apolipoprotein A-IV b, tandem duplicate 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9NZC6, B3DHC5, B3DHC6
      Related
      ENSDARP00000114649.1, ENSDART00000142168.2
      Conserved Domains (1) summary
      pfam01442
      Location:71 → 234
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools