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    shhb sonic hedgehog signaling molecule b [ Danio rerio (zebrafish) ]

    Gene ID: 30444, updated on 2-Nov-2024

    Summary

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    Official Symbol
    shhbprovided by ZNC
    Official Full Name
    sonic hedgehog signaling molecule bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-41
    See related
    Ensembl:ENSDARG00000038867 AllianceGenome:ZFIN:ZDB-GENE-980526-41
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    twh; twhh
    Summary
    Predicted to enable several functions, including calcium ion binding activity; cholesterol-protein transferase activity; and patched binding activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; endocardial cell differentiation; and nervous system development. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including axis; central nervous system; head; neural keel; and neural plate. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and solitary median maxillary central incisor. Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See shhb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30050547..30055381, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30067014..30071848, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 1 Neighboring gene RNA binding motif protein 33b Neighboring gene DnaJ heat shock protein family (Hsp40) member B6a Neighboring gene transient receptor potential cation channel, subfamily A, member 1a Neighboring gene potassium voltage-gated channel subfamily B member 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity. Holley SA, et al. Genes Dev, 2000 Jul 1. PMID 10887161, Free PMC Article
    2. Effective targeted gene 'knockdown' in zebrafish. Nasevicius A, et al. Nat Genet, 2000 Oct. PMID 11017081
    3. A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12. Burger A, et al. Dis Model Mech, 2014 Jul. PMID 24311731, Free PMC Article
    4. Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families. Du SJ, et al. J Cell Biol, 1997 Oct 6. PMID 9314535, Free PMC Article
    5. Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Distel M, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19628697, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation
      Title: Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables patched binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic neurocranium morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endocardial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gliogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in self proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within striated muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tiggy-winkle hedgehog protein
    Names
    sonic hedgehog b
    sonic hedgehog protein B
    tiggy winkle hedge hog
    tiggy winkle hedgehog
    twiggy-winkle hedgehog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131199.2 → NP_571274.2  tiggy-winkle hedgehog protein precursor

      See identical proteins and their annotated locations for NP_571274.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078321
      UniProtKB/Swiss-Prot
      O13212, Q90419
      UniProtKB/TrEMBL
      Q6DBX7
      Related
      ENSDARP00000056746.3, ENSDART00000056747.4
      Conserved Domains (3) summary
      cd00081
      Location:201 → 345
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:190 → 403
      Hint; Hint module
      pfam01085
      Location:42 → 187
      HH_signal; Hedgehog amino-terminal signalling domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      30050547..30055381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90419.1 GenPept UniProtKB/Swiss-Prot:Q90419

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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