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    retsat.2 retinol saturase, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 325922, updated on 14-Nov-2024

    Summary

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    Official Symbol
    retsat.2provided by ZNC
    Official Full Name
    retinol saturase, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-11
    See related
    Ensembl:ENSDARG00000018600 AllianceGenome:ZFIN:ZDB-GENE-050320-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    retsat; RetSat A; wu:fd46d06; zgc:113107
    Summary
    Enables all-trans-retinol 13,14-reductase activity. Acts upstream of or within retinol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gut and liver. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See retsat.2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (39181392..39190264, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (39039534..39048406, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene supervillin c Neighboring gene uncharacterized LOC137490707 Neighboring gene cyclin-dependent kinase 21 Neighboring gene retinol saturase, tandem duplicate 1 Neighboring gene CD209 antigen-like protein C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Moise AR, et al. Biochemistry, 2007 Feb 20. PMID 17253779, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113107

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables all-trans-retinol 13,14-reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol 13,14-reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol 13,14-reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    all-trans-retinol 13,14-reductase
    Names
    all-trans-13,14-dihydroretinol saturase A
    all-trans-retinol 7,8-reductase
    putative all-trans-retinol 13,14-reductase
    retinol saturase (all-trans-retinol 13,14-reductase)
    zRetSat A
    NP_001015061.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015061.2 → NP_001015061.1  all-trans-retinol 13,14-reductase precursor

      See identical proteins and their annotated locations for NP_001015061.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090469
      UniProtKB/Swiss-Prot
      Q5BLE8, Q6DBT4
      Related
      ENSDARP00000024120.7, ENSDART00000013167.8
      Conserved Domains (3) summary
      COG0446
      Location:15 → 99
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      COG1233
      Location:61 → 562
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:64 → 570
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      39181392..39190264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BLE8.1 GenPept UniProtKB/Swiss-Prot:Q5BLE8

    Gene LinkOut

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