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    entpd4 ectonucleoside triphosphate diphosphohydrolase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 436692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    entpd4provided by ZNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-116
    See related
    Ensembl:ENSDARG00000038422 AllianceGenome:ZFIN:ZDB-GENE-040718-116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92668; wu:fd44h12; wu:fi73e02
    Summary
    Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in CTP metabolic process and UDP catabolic process. Predicted to be active in Golgi apparatus and membrane. Is expressed in brain; female organism; heart; and liver. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See entpd4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (50150831..50180226)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (50162134..50191580)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100535162 Neighboring gene microseminoprotein, beta-like Neighboring gene solute carrier family 25 member 37 Neighboring gene NK3 homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart. Rosemberg DB, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Mar. PMID 19922813
    2. A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. Hugo SE, et al. Endocrinology, 2017 Aug 1. PMID 28582574, Free PMC Article
    3. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. Levi L, et al. BMC Genomics, 2009 Mar 31. PMID 19335895, Free PMC Article
    4. Identification of zygotic genes expressed at the midblastula transition in zebrafish. O'Boyle S, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17490614
    5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 4
    Names
    NTPDase4
    NP_001002419.1
    XP_005167275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002419.1 → NP_001002419.1  ectonucleoside triphosphate diphosphohydrolase 4

      See identical proteins and their annotated locations for NP_001002419.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076152
      UniProtKB/TrEMBL
      A0A8M1N0H4, A0A8M9Q3E6, Q6DH30
      Related
      ENSDARP00000056073.5, ENSDART00000056074.6
      Conserved Domains (1) summary
      cl17037
      Location:82 → 532
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      50150831..50180226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167218.5 → XP_005167275.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEM8, A0A8M9Q3E6
      Conserved Domains (1) summary
      cl17037
      Location:82 → 540
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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