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    marchf5l membrane-associated ring finger (C3HC4) 5, like [ Danio rerio (zebrafish) ]

    Gene ID: 326067, updated on 2-Nov-2024

    Summary

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    Official Symbol
    marchf5lprovided by ZNC
    Official Full Name
    membrane-associated ring finger (C3HC4) 5, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4792
    See related
    Ensembl:ENSDARG00000028559 AllianceGenome:ZFIN:ZDB-GENE-030131-4792
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    march5; march5l; marchf5; zgc:56713; wu:fd60f03
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination; protein polyubiquitination; and regulation of mitochondrial fission. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See marchf5l in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (42500918..42519689, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (42672538..42691309, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5Ba Neighboring gene neuropeptide Y receptor Y8a Neighboring gene actin related protein 1B Neighboring gene potassium channel tetramerization domain containing 9b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. Xiong ST, et al. Int J Biol Macromol, 2023 Jun 15. PMID 37054851
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF5
    Names
    E3 ubiquitin-protein ligase MARCH5
    MARCH-V
    RING-type E3 ubiquitin transferase MARCH5
    RING-type E3 ubiquitin transferase MARCHF5
    membrane-associated RING finger protein 5
    membrane-associated RING-CH protein V
    NP_956033.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199739.3 → NP_956033.2  E3 ubiquitin-protein ligase MARCHF5

      See identical proteins and their annotated locations for NP_956033.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066555
      UniProtKB/Swiss-Prot
      Q6NYK8
      Related
      ENSDARP00000037207.6, ENSDART00000039187.8
      Conserved Domains (1) summary
      smart00744
      Location:11 → 67
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      42500918..42519689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYK8.1 GenPept UniProtKB/Swiss-Prot:Q6NYK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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