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    esf1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 326718, updated on 2-Nov-2024

    Summary

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    Official Symbol
    esf1provided by ZNC
    Official Full Name
    ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4917
    See related
    Ensembl:ENSDARG00000008740 AllianceGenome:ZFIN:ZDB-GENE-030131-4917
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe06g12; zgc:66241; im:7138472; wu:fe06g12
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within neural crest cell development; pharyngeal system development; and rRNA processing. Predicted to be located in nucleolus. Is expressed in several structures, including digestive system; head; immature eye; midbrain neural rod; and pectoral fin bud. Orthologous to human ESF1 (ESF1 nucleolar pre-rRNA processing protein homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See esf1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (51202984..51219965, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (50559185..50576166, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene jagged canonical Notch ligand 1a Neighboring gene BTB (POZ) domain containing 3a Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5 Neighboring gene kinesin family member 16Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases. Wu N, et al. Comput Struct Biotechnol J, 2019. PMID 31360334, Free PMC Article
    2. The ribosome biogenesis protein Esf1 is essential for pharyngeal cartilage formation in zebrafish. Chen JY, et al. FEBS J, 2018 Sep. PMID 30073783
    3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pharyngeal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ESF1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199745.2 → NP_956039.2  ESF1 homolog

      Status: PROVISIONAL

      Source sequence(s)
      CU138540
      UniProtKB/TrEMBL
      A0A8M1PBS9, B8JKQ1
      Related
      ENSDARP00000113328.1, ENSDART00000146612.2
      Conserved Domains (2) summary
      COG5638
      Location:8 → 719
      COG5638; Uncharacterized conserved protein [Function unknown]
      pfam08159
      Location:661 → 689
      NUC153; NUC153 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      51202984..51219965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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