fga fibrinogen alpha chain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgaprovided by ZNC
Official Full Name: fibrinogen alpha chainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031010-21
See related: Ensembl:ENSDARG00000020741 AllianceGenome:ZFIN:ZDB-GENE-031010-21
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb892; zgc:92117; wu:fa55c12; wu:fb20e08; wu:fb59b03; wu:fi39d04
Summary: Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within blood coagulation, fibrin clot formation; platelet aggregation; and positive regulation of blood coagulation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Is expressed in blood plasma; liver; and yolk syncytial layer. Used to study congenital afibrinogenemia and vascular hemostatic disease. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (10066100..10071522, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (9381989..9387411, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AalphaE in early hemostasis.
Title: A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis.
fga mutants showed hemorrhaging and reduced survival compared with control animals.This model will serve in the search for afibrinogenemia modifying genes or agents and, is the first transmissible zebrafish model of a defined human bleeding disorder.
Title: Targeted mutation of zebrafish fga models human congenital afibrinogenemia.

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General gene information

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Markers

aa658652 (e-PCR)
- UniSTS:186918

fb20e08.x1 (e-PCR)
- UniSTS:203048

fb59b03.x1 (e-PCR)
- UniSTS:203340

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in blood coagulation, common pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibrinolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet activation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of fibrinogen complex	IBA Inferred from Biological aspect of Ancestor more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibrinogen alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001194989.1 → NP_001181918.1 fibrinogen alpha chain precursor

Status: VALIDATED

Source sequence(s)

BX548256

UniProtKB/TrEMBL

A0A8M1NUN6, B8A5L6

Related

ENSDARP00000029074.5, ENSDART00000033118.6

Conserved Domains (2) summary

cd00087
Location:453 → 684

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:46 → 185

Fib_alpha; Fibrinogen alpha/beta chain family