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    paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [ Danio rerio (zebrafish) ]

    Gene ID: 321193, updated on 2-Nov-2024

    Summary

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    Official Symbol
    paicsprovided by ZNC
    Official Full Name
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9762
    See related
    Ensembl:ENSDARG00000033539 AllianceGenome:ZFIN:ZDB-GENE-030131-9762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb293; sb:cb293; wu:fa28a05
    Summary
    Predicted to enable phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Acts upstream of or within chordate embryonic development; pigmentation; and retina development in camera-type eye. Is expressed in several structures, including eye; immature eye; midbrain; neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See paics in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25618116..25631256, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (25719026..25726972, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily J, polypeptide 20 Neighboring gene uncharacterized LOC110438177 Neighboring gene uncharacterized LOC137488651 Neighboring gene uncharacterized LOC137488652 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene si:dkeyp-117h8.4 Neighboring gene aminoadipate-semialdehyde dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. Ng A, et al. Development, 2009 Aug. PMID 19570845, Free PMC Article
    2. An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. Greenhill ER, et al. PLoS Genet, 2011 Sep. PMID 21909283, Free PMC Article
    3. Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. Weger M, et al. EBioMedicine, 2018 Oct. PMID 30266295, Free PMC Article
    4. Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. Yin X, et al. PLoS One, 2014. PMID 25062015, Free PMC Article
    5. Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Lewis VM, et al. Proc Natl Acad Sci U S A, 2019 Jun 11. PMID 31138706, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two recessive zebrafish mutations that affect de novo purine synthesis, gart and paics, were analyzed.
      Title: Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazole carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
    Names
    multifunctional protein ADE2
    NP_955831.1
    XP_068071481.1
    XP_068071482.1
    XP_068071483.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199537.3 → NP_955831.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

      See identical proteins and their annotated locations for NP_955831.1

      Status: VALIDATED

      Source sequence(s)
      CR352243
      UniProtKB/TrEMBL
      F6NHZ6, F6NI72, Q7ZUN6
      Related
      ENSDARP00000120562.1, ENSDART00000136475.3
      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      25618116..25631256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215380.1 → XP_068071481.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1

      Related
      ENSDARP00000048163.5, ENSDART00000048164.6

    2. XM_068215381.1 → XP_068071482.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

      Related
      ENSDARP00000116949.1, ENSDART00000132247.3

    3. XM_068215382.1 → XP_068071483.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

      Related
      ENSDARP00000109219.2, ENSDART00000126716.4
    Nucleotide Protein Strain
    Heading Accession and Version

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