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    cry3b cryptochrome circadian regulator 3b [ Danio rerio (zebrafish) ]

    Gene ID: 83780, updated on 14-Nov-2024

    Summary

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    Official Symbol
    cry3bprovided by ZNC
    Official Full Name
    cryptochrome circadian regulator 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010426-5
    See related
    Ensembl:ENSDARG00000091131 AllianceGenome:ZFIN:ZDB-GENE-010426-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cry2b; cry1bb; zcry2b
    Summary
    Predicted to enable DNA binding activity and FAD binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; endocrine system; eye; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cry3b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (786543..808901)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (747802..792003)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 76 Neighboring gene retinoblastoma binding protein 5 Neighboring gene zgc:153675 Neighboring gene cryptochrome circadian regulator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA. Ishikawa T, et al. Genes Cells, 2002 Oct. PMID 12354100
    2. Midnight/midday-synchronized expression of cryptochrome genes in the eyes of three teleost species, zebrafish, goldfish, and medaka. Nakagawa M, et al. Zoological Lett, 2022 Jun 7. PMID 35672786, Free PMC Article
    3. A photoperiodic time measurement served by the biphasic expression of Cryptochrome1ab in the zebrafish eye. Okano K, et al. Sci Rep, 2020 Mar 19. PMID 32193419, Free PMC Article
    4. Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish. Kobayashi Y, et al. Genes Cells, 2000 Sep. PMID 10971654
    5. Single-cell in vivo imaging of cellular circadian oscillators in zebrafish. Wang H, et al. PLoS Biol, 2020 Mar. PMID 32168317, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cryptochrome circadian regulator 3b
    Names
    cryptochrome 2b
    cryptochrome circadian clock 1bb
    cryptochrome circadian regulator 1bb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131792.2 → NP_571867.2  cryptochrome circadian regulator 3b

      Status: VALIDATED

      Source sequence(s)
      CF995949, DT066237, EH497225, EH523517, EH530941, FP085425
      UniProtKB/TrEMBL
      A0A8M1PCZ5
      Related
      ENSDARP00000108036.2, ENSDART00000125347.3
      Conserved Domains (3) summary
      COG0415
      Location:5 → 494
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam00875
      Location:5 → 166
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:213 → 489
      FAD_binding_7; FAD binding domain of DNA photolyase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      786543..808901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295768.3 → XP_009294043.2  cryptochrome circadian regulator 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M3AXA7
      Conserved Domains (2) summary
      pfam03441
      Location:293 → 489
      FAD_binding_7; FAD binding domain of DNA photolyase
      cl27275
      Location:5 → 494
      DNA_photolyase; DNA photolyase

    2. XM_021469382.2 → XP_021325057.1  cryptochrome circadian regulator 3b isoform X2

      UniProtKB/TrEMBL
      A0A8M9P4C5
      Related
      ENSDARP00000150344.1, ENSDART00000180188.1
      Conserved Domains (2) summary
      pfam03441
      Location:293 → 489
      FAD_binding_7; FAD binding domain of DNA photolyase
      cl27275
      Location:5 → 494
      DNA_photolyase; DNA photolyase

    3. XM_068216376.1 → XP_068072477.1  cryptochrome circadian regulator 3b isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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