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    setd3 SET domain containing 3, actin histidine methyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 337193, updated on 14-Nov-2024

    Summary

    Official Symbol
    setd3provided by ZNC
    Official Full Name
    SET domain containing 3, actin histidine methyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9137
    See related
    Ensembl:ENSDARG00000016513 AllianceGenome:ZFIN:ZDB-GENE-030131-9137
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb01d12; zgc:63842; wu:fb01d12
    Summary
    Enables histone H3K36 methyltransferase activity and transcription coactivator activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within chromatin remodeling. Predicted to be located in cytoplasm. Is expressed in telencephalon. Orthologous to human SETD3 (SET domain containing 3, actin N3(tau)-histidine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Genomic context

    See setd3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (18031899..18070787)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (18012063..18050951)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene HHIP-like 1 Neighboring gene coiled-coil domain containing 85C, a Neighboring gene BCL11 transcription factor B a Neighboring gene uncharacterized LOC110438061

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K36 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-L-histidine N-tele-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-L-histidine N-tele-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-L-histidine N-tele-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within actin modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-histidine methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of uterine smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin-histidine N-methyltransferase
    Names
    SET domain-containing protein 3
    histone-lysine N-methyltransferase setd3
    protein-L-histidine N-tele-methyltransferase
    NP_956348.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200054.1NP_956348.1  actin-histidine N-methyltransferase

      See identical proteins and their annotated locations for NP_956348.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055261
      UniProtKB/Swiss-Prot
      A9JTB8, Q7SXS7
      Related
      ENSDARP00000005500.5, ENSDART00000022758.7
      Conserved Domains (2) summary
      pfam00856
      Location:275314
      SET; SET domain
      pfam09273
      Location:353475
      Rubis-subs-bind; Rubisco LSMT substrate-binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      18031899..18070787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_011006883.1 RNA Sequence