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    chka choline kinase alpha [ Danio rerio (zebrafish) ]

    Gene ID: 558499, updated on 2-Nov-2024

    Summary

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    Official Symbol
    chkaprovided by ZNC
    Official Full Name
    choline kinase alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-149
    See related
    Ensembl:ENSDARG00000041078 AllianceGenome:ZFIN:ZDB-GENE-050208-149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7143625; wu:fd46h01; si:dkey-12e7.3
    Summary
    Predicted to enable choline kinase activity and ethanolamine kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Is expressed in swim bladder. Orthologous to human CHKA (choline kinase alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See chka in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (21122763..21145374)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (21133699..21156308)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:dkey-12e7.1 Neighboring gene lysine methyltransferase 5B Neighboring gene si:dkey-12e7.4 Neighboring gene synaptotagmin XIX

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Fu J, et al. Environ Sci Technol, 2013 Sep 17. PMID 23919627
    2. Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio). Watt AT, et al. J Nutr Biochem, 2021 Nov. PMID 34119630, Free PMC Article
    3. Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish. Chen T, et al. Genetics, 2018 Mar. PMID 29339408, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables choline kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    choline kinase alpha
    NP_001038330.1
    XP_005159162.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044865.1 → NP_001038330.1  choline kinase alpha

      Status: PROVISIONAL

      Source sequence(s)
      BX571884
      UniProtKB/TrEMBL
      A0A8M1N9Q7, Q1LWF2
      Related
      ENSDARP00000060014.6, ENSDART00000060015.8
      Conserved Domains (2) summary
      PLN02236
      Location:58 → 398
      PLN02236; choline kinase
      cd05156
      Location:73 → 395
      ChoK_euk; Euykaryotic Choline Kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      21122763..21145374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159105.5 → XP_005159162.1  choline kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5P0, Q1LWF1
      Related
      ENSDARP00000060183.5, ENSDART00000060184.6
      Conserved Domains (2) summary
      PLN02236
      Location:58 → 416
      PLN02236; choline kinase
      cd05156
      Location:73 → 413
      ChoK_euk; Euykaryotic Choline Kinase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395023.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      105678..128080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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