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    pcdh10a protocadherin 10a [ Danio rerio (zebrafish) ]

    Gene ID: 259186, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pcdh10aprovided by ZNC
    Official Full Name
    protocadherin 10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020731-1
    See related
    Ensembl:ENSDARG00000099729 AllianceGenome:ZFIN:ZDB-GENE-020731-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pcr1; ZPCR1; pcdh10; fc56b06; wu:fc56b06; wu:fq40g12
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within melanocyte migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; nervous system; neural crest; neural tube; and optic vesicle. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pcdh10a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12763436..12797552)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (12076617..12110750)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489977 Neighboring gene uncharacterized LOC137495458 Neighboring gene uncharacterized LOC137495459 Neighboring gene protocadherin 18a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. Amo R, et al. J Neurosci, 2010 Jan 27. PMID 20107084, Free PMC Article
    2. Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Williams JS, et al. Dev Biol, 2018 Dec 1. PMID 29604249, Free PMC Article
    3. Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Zhou X, et al. Oncotarget, 2016 Dec 13. PMID 27756875, Free PMC Article
    4. Chamber identity programs drive early functional partitioning of the heart. Mosimann C, et al. Nat Commun, 2015 Aug 26. PMID 26306682, Free PMC Article
    5. Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. Turner KJ, et al. PLoS One, 2019. PMID 30695021, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within melanocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin-10a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212571.1 → NP_997736.1  protocadherin-10a precursor

      See identical proteins and their annotated locations for NP_997736.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066445
      UniProtKB/TrEMBL
      A0A8M1PKR2, Q6NYV7
      Related
      ENSDARP00000144991.1, ENSDART00000180121.1
      Conserved Domains (3) summary
      cd11304
      Location:233 → 333
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:17 → 99
      Cadherin_2; Cadherin-like
      pfam16492
      Location:677 → 791
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      12763436..12797552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306587.4 → XP_009304862.1  protocadherin-10a isoform X1

      UniProtKB/TrEMBL
      A0A2R8QI99, A0A8M3BE35
      Related
      ENSDARP00000152743.1, ENSDART00000189465.1
      Conserved Domains (3) summary
      cd11304
      Location:233 → 333
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:17 → 99
      Cadherin_2; Cadherin-like
      pfam16492
      Location:677 → 791
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    2. XM_009306589.4 → XP_009304864.1  protocadherin-10a isoform X2

      UniProtKB/TrEMBL
      A0A8M3B7B9
      Conserved Domains (3) summary
      cd11304
      Location:233 → 333
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:17 → 99
      Cadherin_2; Cadherin-like
      pfam16492
      Location:677 → 791
      Cadherin_C_2; Cadherin cytoplasmic C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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