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    bmi1b bmi1 polycomb ring finger oncogene 1b [ Danio rerio (zebrafish) ]

    Gene ID: 394249, updated on 2-Nov-2024

    Summary

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    Official Symbol
    bmi1bprovided by ZNC
    Official Full Name
    bmi1 polycomb ring finger oncogene 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040116-4
    See related
    Ensembl:ENSDARG00000013076 AllianceGenome:ZFIN:ZDB-GENE-040116-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pcgf4b
    Summary
    Predicted to enable promoter-specific chromatin binding activity. Acts upstream of or within cerebellum development. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to human BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See bmi1b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (21164930..21170517, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21506872..21512207, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene nebulette Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b Neighboring gene si:dkey-29d8.3 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. Dupret B, et al. PLoS One, 2016. PMID 27442247, Free PMC Article
    2. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Mochida GH, et al. Nat Genet, 2012 Nov. PMID 23023333, Free PMC Article
    3. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. Janjuha S, et al. Elife, 2018 Apr 6. PMID 29624168, Free PMC Article
    4. A histone demethylase is necessary for regeneration in zebrafish. Stewart S, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19897725, Free PMC Article
    5. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebellum development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polycomb complex protein BMI-1-B
    Names
    B lymphoma Mo-MLV insertion region 1b
    polycomb group RING finger protein 4-B
    polycomb group ring finger 4 B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080751.2 → NP_001074220.1  polycomb complex protein BMI-1-B

      See identical proteins and their annotated locations for NP_001074220.1

      Status: VALIDATED

      Source sequence(s)
      CR388093
      UniProtKB/Swiss-Prot
      Q7T3E6
      Related
      ENSDARP00000115422.1, ENSDART00000135417.3
      Conserved Domains (2) summary
      pfam00097
      Location:18 → 56
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:146 → 224
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      21164930..21170517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479461.2 → XP_021335136.1  polycomb complex protein BMI-1-B isoform X1

      UniProtKB/TrEMBL
      A0A8M9QHB6
      Related
      ENSDARP00000157311.1, ENSDART00000185792.1
      Conserved Domains (3) summary
      pfam16207
      Location:162 → 226
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16736
      Location:14 → 67
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cl28410
      Location:10 → 153
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T3E6.1 GenPept UniProtKB/Swiss-Prot:Q7T3E6

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