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    ela2l elastase 2 like [ Danio rerio (zebrafish) ]

    Gene ID: 334304, updated on 2-Nov-2024

    Summary

    Official Symbol
    ela2lprovided by ZNC
    Official Full Name
    elastase 2 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040511-1
    See related
    Ensembl:ENSDARG00000056765 AllianceGenome:ZFIN:ZDB-GENE-040511-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctrc; fi40a05; elastaseB; zgc:63744; wu:fi40a05; zgc:111871
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in exocrine pancreas; liver; and pancreas. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 4. Orthologous to human CTRC (chymotrypsin C); CELA2A (chymotrypsin like elastase 2A); and CELA2B (chymotrypsin like elastase 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See ela2l in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (21369055..21372443, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (21336970..21340358, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor, type 3 Neighboring gene G protein-coupled receptor 37 like 1b Neighboring gene aminolevulinate, delta-, synthase 2 Neighboring gene uncharacterized LOC137490313 Neighboring gene elastase 2 Neighboring gene forkhead-associated (FHA) phosphopeptide binding domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC111871

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    elastase 2 like
    Names
    caldecrin
    chymotrypsin C
    elastase B
    NP_956180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199886.1NP_956180.1  elastase 2 like precursor

      See identical proteins and their annotated locations for NP_956180.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054136
      UniProtKB/TrEMBL
      Q7SZ51
      Related
      ENSDARP00000073749.5, ENSDART00000079293.6
      Conserved Domains (2) summary
      smart00020
      Location:28260
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:29263
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      21369055..21372443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394721.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      119959..123353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)