KLF7 KLF transcription factor 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF7provided by HGNC
Official Full Name: KLF transcription factor 7provided by HGNC
Primary source: HGNC:HGNC:6350
See related: Ensembl:ENSG00000118263 MIM:604865; AllianceGenome:HGNC:6350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UKLF
Summary: The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression: Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (207074137..207173851, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (207556313..207657581, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (207938861..208031970, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF7 promotes neuroblastoma differentiation through the GTPase signaling pathway by upregulating neuroblast differentiation-associated protein AHNAKs and glycerophosphodiesterase GDPD5.
Title: KLF7 promotes neuroblastoma differentiation through the GTPase signaling pathway by upregulating neuroblast differentiation-associated protein AHNAKs and glycerophosphodiesterase GDPD5.
Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.
Title: Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.
KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis.
Title: KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis.
UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
Title: UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.
Title: KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.
HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2.
Title: HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2.
Molecular function of Kruppel-like factor 7 in biology.
Title: Molecular function of Krüppel-like factor 7 in biology.
Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression.
Title: Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression.
LncRNA NUTM2A-AS1 aggravates the progression of hepatocellular carcinoma by activating the miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway.
Title: LncRNA NUTM2A-AS1 aggravates the progression of hepatocellular carcinoma by activating the miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway.
Kruppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.
Title: Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-106368 (e-PCR)
- UniSTS:169796

WI-13455 (e-PCR)
- UniSTS:23422

RH15615 (e-PCR)
- UniSTS:87484

RH103134 (e-PCR)
- UniSTS:97468

SHGC-52791 (e-PCR)
- UniSTS:12733

RH18337 (e-PCR)
- UniSTS:63422

RH78593 (e-PCR)
- UniSTS:75235

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 7

Names: Kruppel like factor 7; Kruppel-like factor 7 (ubiquitous); ubiquitous Kruppel-like factor; ubiquitous Kruppel-like transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052989.2 RefSeqGene

Range

12903..104714

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270942.1 → NP_001257871.1 Krueppel-like factor 7 isoform 2

See identical proteins and their annotated locations for NP_001257871.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC008062, BC012919, DA800775

Consensus CDS

CCDS59439.1

UniProtKB/Swiss-Prot

O75840

Related

ENSP00000398572.1, ENST00000423015.5
NM_001270943.2 → NP_001257872.1 Krueppel-like factor 7 isoform 3

See identical proteins and their annotated locations for NP_001257872.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC007879, AC008062

Consensus CDS

CCDS59440.1

UniProtKB/TrEMBL

Q4ZG79

Related

ENSP00000387510.1, ENST00000421199.5

Conserved Domains (3) summary

COG5048
Location:179 → 251

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:191 → 210

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:246 → 268

zf-C2H2; Zinc finger, C2H2 type
NM_001270944.2 → NP_001257873.1 Krueppel-like factor 7 isoform 4

See identical proteins and their annotated locations for NP_001257873.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC007879, AC008062

Consensus CDS

CCDS59438.1

UniProtKB/TrEMBL

Q4ZG79

Related

ENSP00000413590.2, ENST00000435602.2

Conserved Domains (3) summary

COG5048
Location:184 → 256

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:196 → 215

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:251 → 273

zf-C2H2; Zinc finger, C2H2 type
NM_003709.4 → NP_003700.1 Krueppel-like factor 7 isoform 1

See identical proteins and their annotated locations for NP_003700.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC007879, AC008062

Consensus CDS

CCDS2373.1

UniProtKB/Swiss-Prot

B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51

UniProtKB/TrEMBL

B3KNE6

Related

ENSP00000309570.6, ENST00000309446.11

Conserved Domains (5) summary

COG5048
Location:212 → 284

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:224 → 243

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:279 → 301

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:265 → 290

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 220

KLF7_N; N-terminal domain of Kruppel-like factor 7

RNA

NR_073108.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC008062, DA023826

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

207074137..207173851 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047446149.1 → XP_047302105.1 Krueppel-like factor 7 isoform X3
XM_047446146.1 → XP_047302102.1 Krueppel-like factor 7 isoform X1

UniProtKB/Swiss-Prot

B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
XM_047446145.1 → XP_047302101.1 Krueppel-like factor 7 isoform X1

UniProtKB/Swiss-Prot

B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
XM_047446147.1 → XP_047302103.1 Krueppel-like factor 7 isoform X1

UniProtKB/Swiss-Prot

B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
XM_047446144.1 → XP_047302100.1 Krueppel-like factor 7 isoform X1

UniProtKB/Swiss-Prot

B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
XM_017005161.2 → XP_016860650.1 Krueppel-like factor 7 isoform X1

UniProtKB/Swiss-Prot

B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51

UniProtKB/TrEMBL

B3KNE6

Conserved Domains (5) summary

COG5048
Location:212 → 284

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:224 → 243

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:279 → 301

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:265 → 290

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 220

KLF7_N; N-terminal domain of Kruppel-like factor 7
XM_017005164.3 → XP_016860653.1 Krueppel-like factor 7 isoform X5

UniProtKB/Swiss-Prot

O75840

Related

ENSP00000515454.1, ENST00000703734.1
XM_047446148.1 → XP_047302104.1 Krueppel-like factor 7 isoform X2
XM_011512075.3 → XP_011510377.1 Krueppel-like factor 7 isoform X4

UniProtKB/TrEMBL

A0A994J6Y4

Conserved Domains (2) summary

sd00017
Location:221 → 243

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:219 → 243

zf-C2H2; Zinc finger, C2H2 type
XM_047446150.1 → XP_047302106.1 Krueppel-like factor 7 isoform X4