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    ZNF862 zinc finger protein 862 [ Homo sapiens (human) ]

    Gene ID: 643641, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF862provided by HGNC
    Official Full Name
    zinc finger protein 862provided by HGNC
    Primary source
    HGNC:HGNC:34519
    See related
    Ensembl:ENSG00000106479 MIM:620974; AllianceGenome:HGNC:34519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity and protein dimerization activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in skin (RPKM 4.4), thyroid (RPKM 4.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF862 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149838375..149867479)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151020282..151049591)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149535464..149564568)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149438995-149439524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149463303-149463978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149479128-149479704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149480282-149480858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149480859-149481434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149482621-149483120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149484857-149485446 Neighboring gene Sharpr-MPRA regulatory region 4172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149487626-149488414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149496913-149497414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149497415-149497914 Neighboring gene zinc finger protein 467 Neighboring gene SCO-spondin, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552405-149552958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552959-149553510 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149570857-149571825 Neighboring gene ATPase H+ transporting V0 subunit e2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:149604113-149604612 Neighboring gene actin related protein 3C Neighboring gene uncharacterized LOC124901772

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts. Zhu Y, et al. J Periodontal Res, 2024 Jun. PMID 38482719
    2. A novel gene ZNF862 causes hereditary gingival fibromatosis. Wu J, et al. Elife, 2022 Feb 10. PMID 35142290, Free PMC Article
    3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Feb 28. PMID 9628581
    4. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    5. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts.
      Title: ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts.
    2. A novel gene ZNF862 causes hereditary gingival fibromatosis.
      Title: A novel gene ZNF862 causes hereditary gingival fibromatosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30362, KIAA0543

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 862

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051961.1 RefSeqGene

      Range
      4410..33514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099220.3 → NP_001092690.1  zinc finger protein 862

      See identical proteins and their annotated locations for NP_001092690.1

      Status: VALIDATED

      Source sequence(s)
      AB011115, AC004877, BC113087, BQ270712, BU164247, DA724031
      Consensus CDS
      CCDS47741.1
      UniProtKB/Swiss-Prot
      A0AUL8, O60290
      Related
      ENSP00000223210.4, ENST00000223210.5
      Conserved Domains (5) summary
      cd07765
      Location:11 → 41
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:333 → 393
      KRAB; krueppel associated box
      smart00597
      Location:135 → 218
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam01352
      Location:333 → 372
      KRAB; KRAB box
      pfam05699
      Location:990 → 1066
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149838375..149867479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516464.2 → XP_011514766.1  zinc finger protein 862 isoform X2

      Conserved Domains (5) summary
      cd07765
      Location:18 → 48
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:340 → 400
      KRAB; krueppel associated box
      smart00597
      Location:142 → 225
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam01352
      Location:340 → 379
      KRAB; KRAB box
      pfam05699
      Location:997 → 1073
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    2. XM_017012519.2 → XP_016868008.1  zinc finger protein 862 isoform X3

    3. XM_024446866.1 → XP_024302634.1  zinc finger protein 862 isoform X4

      Conserved Domains (3) summary
      smart00349
      Location:249 → 309
      KRAB; krueppel associated box
      smart00597
      Location:51 → 134
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:906 → 982
      Dimer_Tnp_hAT; hAT family C-terminal dimerisation region

    4. XM_006716085.4 → XP_006716148.1  zinc finger protein 862 isoform X1

      See identical proteins and their annotated locations for XP_006716148.1

      Conserved Domains (5) summary
      cd07765
      Location:25 → 55
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:347 → 407
      KRAB; krueppel associated box
      smart00597
      Location:149 → 232
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam01352
      Location:347 → 386
      KRAB; KRAB box
      pfam05699
      Location:1004 → 1080
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    5. XM_011516463.1 → XP_011514765.1  zinc finger protein 862 isoform X1

      See identical proteins and their annotated locations for XP_011514765.1

      Conserved Domains (5) summary
      cd07765
      Location:25 → 55
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:347 → 407
      KRAB; krueppel associated box
      smart00597
      Location:149 → 232
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam01352
      Location:347 → 386
      KRAB; KRAB box
      pfam05699
      Location:1004 → 1080
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    6. XM_011516465.3 → XP_011514767.1  zinc finger protein 862 isoform X5

      Conserved Domains (2) summary
      smart00597
      Location:137 → 220
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:666 → 742
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    7. XM_011516466.3 → XP_011514768.1  zinc finger protein 862 isoform X6

      Conserved Domains (2) summary
      smart00597
      Location:50 → 133
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:579 → 655
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151020282..151049591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60290.2 GenPept UniProtKB/Swiss-Prot:O60290

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