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    IGFLR1 IGF like family receptor 1 [ Homo sapiens (human) ]

    Gene ID: 79713, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IGFLR1provided by HGNC
    Official Full Name
    IGF like family receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:23620
    See related
    Ensembl:ENSG00000126246 MIM:614143; AllianceGenome:HGNC:23620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM149
    Summary
    Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in lymph node (RPKM 16.7), spleen (RPKM 14.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IGFLR1 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35738801..35742452, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38284115..38287764, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36229702..36233353, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36174493-36174994 Neighboring gene thymidylate synthetase pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14492 Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10532 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:36207458-36208017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36209137-36209694 Neighboring gene lysine methyltransferase 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36230671-36231301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14497 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36234871-36235031 Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 Neighboring gene presenilin enhancer, gamma-secretase subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. Lobito AA, et al. J Biol Chem, 2011 May 27. PMID 21454693, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
      Title: Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22573

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    IGF-like family receptor 1
    Names
    transmembrane protein 149

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346003.2 → NP_001332932.1  IGF-like family receptor 1 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AD000671
      Consensus CDS
      CCDS86752.1
      UniProtKB/TrEMBL
      K7EL86
      Related
      ENSP00000465962.1, ENST00000588992.5

    2. NM_001346004.2 → NP_001332933.1  IGF-like family receptor 1 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
      Source sequence(s)
      AD000671
      Consensus CDS
      CCDS86751.1
      UniProtKB/Swiss-Prot
      Q9H665
      Related
      ENSP00000467750.1, ENST00000592889.1

    3. NM_001346005.2 → NP_001332934.1  IGF-like family receptor 1 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
      Source sequence(s)
      AD000671
      Consensus CDS
      CCDS86751.1
      UniProtKB/Swiss-Prot
      Q9H665

    4. NM_001346006.2 → NP_001332935.1  IGF-like family receptor 1 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AD000671
      UniProtKB/TrEMBL
      K7ES44

    5. NM_024660.4 → NP_078936.1  IGF-like family receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_078936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AD000671, AK026226, BU621457
      Consensus CDS
      CCDS12472.1
      UniProtKB/Swiss-Prot
      Q8N5X0, Q9H665
      Related
      ENSP00000246532.1, ENST00000246532.6

    RNA

    1. NR_144338.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AD000671, AK026226, BC144205, BU621457

    2. NR_144339.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AD000671

    3. NR_144340.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AD000671

    4. NR_144341.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AD000671

    5. NR_144342.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AD000671

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35738801..35742452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38284115..38287764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H665.1 GenPept UniProtKB/Swiss-Prot:Q9H665

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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