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    CACYBP calcyclin binding protein [ Homo sapiens (human) ]

    Gene ID: 27101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CACYBPprovided by HGNC
    Official Full Name
    calcyclin binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30423
    See related
    Ensembl:ENSG00000116161 MIM:606186; AllianceGenome:HGNC:30423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP; GIG5; PNAS-107; S100A6BP
    Summary
    The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 20.4), ovary (RPKM 13.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CACYBP in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (174999435..175012027)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (174353190..174365783)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (174968571..174981163)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 like Neighboring gene RABGAP1L antisense RNA 1 Neighboring gene uncharacterized LOC105371622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:174968357-174968892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1566 Neighboring gene MPRA-validated peak469 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175012695-175013230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175013231-175013766 Neighboring gene RNA, U6 small nuclear 307, pseudogene Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene ENTR1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5. Bai M, et al. Carcinogenesis, 2024 Aug 12. PMID 38558058
    2. iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis. Ghosh D, et al. Mol Cell Proteomics, 2013 Jul. PMID 23543800, Free PMC Article
    3. CacyBP/SIP protein is important for the proliferation of human glioma cells. Shi H, et al. IUBMB Life, 2014 Apr. PMID 24740456
    4. CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation. Zhai HH, et al. World J Gastroenterol, 2014 Aug 7. PMID 25110433, Free PMC Article
    5. CacyBP/SIP protein promotes proliferation and G1/S transition of human pancreatic cancer cells. Chen X, et al. Mol Carcinog, 2011 Oct. PMID 21268134

    See all (186) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5.
      Title: CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5.
    2. CACYBP knockdown inhibits progression of prostate cancer via p53.
      Title: CACYBP knockdown inhibits progression of prostate cancer via p53.
    3. The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.
      Title: The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.
    4. Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.
      Title: Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.
    5. Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.
      Title: Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.
    6. Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and beta-Catenin Signaling.
      Title: Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.
    7. [CacyBP promotes the proliferation and invasion of non-small cell lung cancer].
      Title: [CacyBP promotes the proliferation and invasion of non-small cell lung cancer].
    8. HSP90 Co-Chaperone, CacyBP/SIP, Protects alpha-Synuclein from Aggregation.
      Title: HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation.
    9. CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.
      Title: CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.
    10. promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation
      Title: SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of calcyclin binding protein (CACYBP) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC87971

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables S100 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcyclin-binding protein
    Names
    S100A6-binding protein
    Siah-interacting protein (SIP)
    growth-inhibiting gene 5 protein
    hCacyBP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029961.2 RefSeqGene

      Range
      5514..17594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007214.1 → NP_001007215.1  calcyclin-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001007215.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, and uses a downstream AUG start codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK093425, AL035305, AW300675, BQ432793
      Consensus CDS
      CCDS30942.1
      UniProtKB/TrEMBL
      Q6NVY0
      Related
      ENSP00000479414.1, ENST00000613570.4
      Conserved Domains (3) summary
      cd06468
      Location:32 → 124
      p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
      pfam05002
      Location:139 → 174
      SGS; SGS domain
      pfam09032
      Location:3 → 32
      Siah-Interact_N; Siah interacting protein, N terminal

    2. NM_014412.3 → NP_055227.1  calcyclin-binding protein isoform 1

      See identical proteins and their annotated locations for NP_055227.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL035305, AW300675, CA951015
      Consensus CDS
      CCDS1315.1
      UniProtKB/Swiss-Prot
      B2ZWH2, B3KSF1, O60666, Q5R370, Q5R371, Q9HB71
      UniProtKB/TrEMBL
      Q6NVY0
      Related
      ENSP00000356652.2, ENST00000367679.7
      Conserved Domains (3) summary
      cd06468
      Location:75 → 167
      p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
      pfam05002
      Location:182 → 217
      SGS; SGS domain
      pfam09032
      Location:4 → 75
      Siah-Interact_N; Siah interacting protein, N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      174999435..175012027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      174353190..174365783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HB71.2 GenPept UniProtKB/Swiss-Prot:Q9HB71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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