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    NUP62 nucleoporin 62 [ Homo sapiens (human) ]

    Gene ID: 23636, updated on 9-Dec-2024

    Summary

    Official Symbol
    NUP62provided by HGNC
    Official Full Name
    nucleoporin 62provided by HGNC
    Primary source
    HGNC:HGNC:8066
    See related
    Ensembl:ENSG00000213024 MIM:605815; AllianceGenome:HGNC:8066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p62; IBSN; SNDI
    Summary
    The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NUP62 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49906825..49929504, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52906960..52929639, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50410082..50432761, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50373269-50373916 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50379233-50380192 Neighboring gene AKT1 substrate 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50381153-50382112 Neighboring gene uncharacterized LOC124904743 Neighboring gene TBC1 domain family member 17 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50393336-50394003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50394004-50394672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50394673-50395339 Neighboring gene microRNA 4750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14967 Neighboring gene interleukin 4 induced 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50411173-50411894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50415677-50416528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50424983-50425650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50425735-50426488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10948 Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene small nucleolar RNA U3 Neighboring gene sialic acid binding Ig like lectin 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nucleoporin 62kDa (NUP62) by shRNA inhibits HIV-1 infection by reducing viral DNA integration in CD4+ C8166 T cells and macrophages PubMed
    Knockdown of nucleoporin 62kDa (NUP62) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev nup62 is involved in Rev-mediated nuclear export of HIV-1 mRNA through an interaction with eukaryotic initiation factor 5A (eIF-5A) which binds to Rev PubMed
    integrase gag-pol HIV-1 IN specifically binds NUP62 through the IN binding domain (residues 328-522) of NUP62 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC841, FLJ20822, FLJ43869, DKFZp547L134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PTB domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH2 domain binding IDA
    Inferred from Direct Assay
    more info
     
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IDA
    Inferred from Direct Assay
    more info
     
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
     
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
     
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
     
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
     
    involved_in positive regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
     
    involved_in positive regulation of mitotic cytokinetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear pore glycoprotein p62
    Names
    62 kDa nucleoporin
    nucleoporin 62kD
    nucleoporin 62kDa
    nucleoporin Nup62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023448.1 RefSeqGene

      Range
      5228..27907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193357.2NP_001180286.1  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_001180286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AL162061, BC050717, BG575286, BM672281, DB076767
      Consensus CDS
      CCDS12788.1
      UniProtKB/Swiss-Prot
      B3KWU5, P37198, Q503A4, Q6GTM2, Q96C43, Q9NSL1
      UniProtKB/TrEMBL
      M0QXN5
      Related
      ENSP00000515007.1, ENST00000700474.1
      Conserved Domains (3) summary
      pfam05064
      Location:328429
      Nsp1_C; Nsp1-like C-terminal region
      pfam13851
      Location:367512
      GAS; Growth-arrest specific micro-tubule binding
      pfam15967
      Location:1255
      Nucleoporin_FG2; Nucleoporin FG repeated region
    2. NM_012346.5NP_036478.2  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_036478.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AL162061, BC050717, BG575286, BM672281, DA856902
      Consensus CDS
      CCDS12788.1
      UniProtKB/Swiss-Prot
      B3KWU5, P37198, Q503A4, Q6GTM2, Q96C43, Q9NSL1
      UniProtKB/TrEMBL
      M0QXN5
      Related
      ENSP00000515006.1, ENST00000700473.1
      Conserved Domains (3) summary
      pfam05064
      Location:328429
      Nsp1_C; Nsp1-like C-terminal region
      pfam13851
      Location:367512
      GAS; Growth-arrest specific micro-tubule binding
      pfam15967
      Location:1255
      Nucleoporin_FG2; Nucleoporin FG repeated region
    3. NM_016553.5NP_057637.2  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_057637.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AL162061, BC050717, BG575286, BM672281, DA949331
      Consensus CDS
      CCDS12788.1
      UniProtKB/Swiss-Prot
      B3KWU5, P37198, Q503A4, Q6GTM2, Q96C43, Q9NSL1
      UniProtKB/TrEMBL
      M0QXN5
      Related
      ENSP00000305503.3, ENST00000352066.8
      Conserved Domains (3) summary
      pfam05064
      Location:328429
      Nsp1_C; Nsp1-like C-terminal region
      pfam13851
      Location:367512
      GAS; Growth-arrest specific micro-tubule binding
      pfam15967
      Location:1255
      Nucleoporin_FG2; Nucleoporin FG repeated region
    4. NM_153718.4NP_714940.1  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_714940.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AL162061, BC050717, BG575286, BM672281, DA438104
      Consensus CDS
      CCDS12788.1
      UniProtKB/Swiss-Prot
      B3KWU5, P37198, Q503A4, Q6GTM2, Q96C43, Q9NSL1
      UniProtKB/TrEMBL
      M0QXN5
      Related
      ENSP00000407331.1, ENST00000422090.2
      Conserved Domains (3) summary
      pfam05064
      Location:328429
      Nsp1_C; Nsp1-like C-terminal region
      pfam13851
      Location:367512
      GAS; Growth-arrest specific micro-tubule binding
      pfam15967
      Location:1255
      Nucleoporin_FG2; Nucleoporin FG repeated region
    5. NM_153719.4NP_714941.1  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_714941.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AL162061, BC050717, BC101107, BG575286, BM672281, DA945913
      Consensus CDS
      CCDS12788.1
      UniProtKB/Swiss-Prot
      B3KWU5, P37198, Q503A4, Q6GTM2, Q96C43, Q9NSL1
      UniProtKB/TrEMBL
      M0QXN5
      Related
      ENSP00000473192.1, ENST00000597029.6
      Conserved Domains (3) summary
      pfam05064
      Location:328429
      Nsp1_C; Nsp1-like C-terminal region
      pfam13851
      Location:367512
      GAS; Growth-arrest specific micro-tubule binding
      pfam15967
      Location:1255
      Nucleoporin_FG2; Nucleoporin FG repeated region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49906825..49929504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52906960..52929639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)