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    S100G S100 calcium binding protein G [ Homo sapiens (human) ]

    Gene ID: 795, updated on 27-Nov-2024

    Summary

    Official Symbol
    S100Gprovided by HGNC
    Official Full Name
    S100 calcium binding protein Gprovided by HGNC
    Primary source
    HGNC:HGNC:1436
    See related
    Ensembl:ENSG00000169906 MIM:302020; AllianceGenome:HGNC:1436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CABP; CABP1; CALB3; CABP9K
    Summary
    This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward duodenum (RPKM 36.4) See more
    Orthologs
    NEW
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    Genomic context

    See S100G in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (16650158..16654670)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (16232624..16237136)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16668281..16672793)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 658, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16593879-16594382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:16595896-16596399 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:16596400-16596904 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:16596905-16597407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:16597568-16598414 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:16598415-16599261 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:16604766-16605549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:16625033-16625533 Neighboring gene CTP synthase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16647850-16648497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16648498-16649144 Neighboring gene microRNA 548am Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29454 Neighboring gene Sharpr-MPRA regulatory region 4999 Neighboring gene synapse associated protein 1 Neighboring gene RNA, U7 small nuclear 56 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138379

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin D binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein S100-G
    Names
    calbindin 3, (vitamin D-dependent calcium-binding protein)
    calbindin D9K
    calbindin-D9k
    vitamin D-dependent calcium-binding protein, intestinal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004057.3NP_004048.1  protein S100-G

      See identical proteins and their annotated locations for NP_004048.1

      Status: REVIEWED

      Source sequence(s)
      AL445467, L13220
      Consensus CDS
      CCDS14176.1
      UniProtKB/Swiss-Prot
      P29377, Q5JS49
      Related
      ENSP00000369547.3, ENST00000380200.3
      Conserved Domains (1) summary
      cd00213
      Location:1279
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      16650158..16654670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029841.2XP_016885330.1  protein S100-G isoform X1

      UniProtKB/Swiss-Prot
      P29377, Q5JS49
      Conserved Domains (1) summary
      cd00213
      Location:1279
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      16232624..16237136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327869.1XP_054183844.1  protein S100-G isoform X1

      UniProtKB/Swiss-Prot
      P29377, Q5JS49