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    GRPR gastrin releasing peptide receptor [ Homo sapiens (human) ]

    Gene ID: 2925, updated on 9-Dec-2024

    Summary

    Official Symbol
    GRPRprovided by HGNC
    Official Full Name
    gastrin releasing peptide receptorprovided by HGNC
    Primary source
    HGNC:HGNC:4609
    See related
    Ensembl:ENSG00000126010 MIM:305670; AllianceGenome:HGNC:4609
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BB2; BB2R; BRS2
    Summary
    Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in pancreas (RPKM 2.4), stomach (RPKM 0.7) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GRPR in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (16123565..16153518)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (15706468..15736420)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16141688..16171641)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U5F small nuclear 7, pseudogene Neighboring gene SET pseudogene 15 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:15961157-15961364 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:16060812-16061354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:16065714-16066214 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:16094875-16095376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29452 Neighboring gene Sharpr-MPRA regulatory region 9466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20677 Neighboring gene MAGEB17 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:16178523-16179722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16186339-16187224 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:16197237-16197862 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:16203427-16204626 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:16204620-16205364 Neighboring gene MAGE family member B17 Neighboring gene ribosomal protein L6 pseudogene 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in motor behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of behavioral fear response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of respiratory gaseous exchange ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in psychomotor behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to external biotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    gastrin-releasing peptide receptor
    Names
    GRP-R
    GRP-preferring bombesin receptor
    bombesin receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012512.1 RefSeqGene

      Range
      5265..35218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005314.3NP_005305.1  gastrin-releasing peptide receptor

      See identical proteins and their annotated locations for NP_005305.1

      Status: REVIEWED

      Source sequence(s)
      AC078993, AU125660, M73481
      Consensus CDS
      CCDS14174.1
      UniProtKB/Swiss-Prot
      B2R910, P30550
      UniProtKB/TrEMBL
      X5D7H2
      Related
      ENSP00000369643.2, ENST00000380289.3
      Conserved Domains (1) summary
      cd15124
      Location:41333
      7tmA_GRPR; gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      16123565..16153518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      15706468..15736420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)