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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_009057.1 RefSeqGene
- Range
-
5001..100045
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_511
mRNA and Protein(s)
-
NM_000268.4 → NP_000259.1 merlin isoform 1
See identical proteins and their annotated locations for NP_000259.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC004882, AF369657
- Consensus CDS
-
CCDS13861.1
- UniProtKB/Swiss-Prot
- O95683, P35240, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000344666.5, ENST00000338641.10
- Conserved Domains (4) summary
-
- PLN03086
Location:307 → 367
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:23 → 222
- B41; Band 4.1 homologues
- cd13194
Location:216 → 312
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:347 → 595
- ERM; Ezrin/radixin/moesin family
-
NM_001407053.1 → NP_001393982.1 merlin isoform 9
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
- Conserved Domains (4) summary
-
- PLN03086
Location:269 → 329
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:1 → 184
- B41; Band 4.1 homologues
- cd13194
Location:178 → 274
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:308 → 557
- ERM; Ezrin/radixin/moesin family
-
NM_001407054.1 → NP_001393983.1 merlin isoform 10
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
-
NM_001407055.1 → NP_001393984.1 merlin isoform 11
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
-
NM_001407056.1 → NP_001393985.1 merlin isoform 12
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
-
NM_001407057.1 → NP_001393986.1 merlin isoform 13
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
- A0A5K1VW66, B7Z4B6
- Related
- ENSP00000354529.6, ENST00000361166.10
- Conserved Domains (4) summary
-
- PLN03086
Location:262 → 322
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:23 → 222
- B41; Band 4.1 homologues
- pfam00769
Location:301 → 550
- ERM; Ezrin/radixin/moesin family
- cl17171
Location:216 → 267
- PH-like; Pleckstrin homology-like domain
-
NM_001407058.1 → NP_001393987.1 merlin isoform 6
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
-
NM_001407059.1 → NP_001393988.1 merlin isoform 14
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
-
NM_001407060.1 → NP_001393989.1 merlin isoform 15
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
-
NM_001407062.1 → NP_001393991.1 merlin isoform 17
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
-
NM_001407063.1 → NP_001393992.1 merlin isoform 7
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
-
NM_001407064.1 → NP_001393993.1 merlin isoform 18
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
-
NM_001407065.1 → NP_001393994.1 merlin isoform 19
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
-
NM_001407066.1 → NP_001393995.1 merlin isoform 2
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000500919.1, ENST00000672461.1
-
NM_001407067.1 → NP_001393996.1 merlin isoform 16
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
-
NM_016418.5 → NP_057502.2 merlin isoform 2
See identical proteins and their annotated locations for NP_057502.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2), one of the two predominant isoforms, has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC004882, AF369658, BC071653, CN419318
- Consensus CDS
-
CCDS13862.1
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000500117.1, ENST00000672896.1
- Conserved Domains (4) summary
-
- PLN03086
Location:307 → 367
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:23 → 222
- B41; Band 4.1 homologues
- cd13194
Location:216 → 312
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:347 → 579
- ERM; Ezrin/radixin/moesin family
-
NM_181825.3 → NP_861546.1 merlin isoform 2
See identical proteins and their annotated locations for NP_861546.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (12) includes an alternate exon and differs in the 3' UTR, compared to variant 1. The resulting protein (isoform 2), one of the two predominant isoforms, has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AF369701
- Consensus CDS
-
CCDS13862.1
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000384797.3, ENST00000403999.7
- Conserved Domains (4) summary
-
- PLN03086
Location:307 → 367
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:23 → 222
- B41; Band 4.1 homologues
- cd13194
Location:216 → 312
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:347 → 579
- ERM; Ezrin/radixin/moesin family
-
NM_181828.3 → NP_861966.1 merlin isoform 5
See identical proteins and their annotated locations for NP_861966.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region and includes an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 5, also referred to as isoform delE2) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC004882, AF369658, AF369663
- Consensus CDS
-
CCDS13863.1
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000355183.4, ENST00000361676.8
- Conserved Domains (4) summary
-
- PLN03086
Location:265 → 325
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:38 → 180
- B41; Band 4.1 homologues
- cd13194
Location:174 → 270
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:305 → 537
- ERM; Ezrin/radixin/moesin family
-
NM_181829.3 → NP_861967.1 merlin isoform 6
See identical proteins and their annotated locations for NP_861967.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks an alternate in-frame exon in the 5' coding region and includes an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 6, also referred to as isoform delE3) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC004882, AF369664, CF138178, CN419318
- Consensus CDS
-
CCDS13864.1
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000354897.4, ENST00000361452.8
- Conserved Domains (4) summary
-
- PLN03086
Location:266 → 326
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:23 → 181
- B41; Band 4.1 homologues
- cd13194
Location:175 → 271
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:306 → 538
- ERM; Ezrin/radixin/moesin family
-
NM_181830.3 → NP_861968.1 merlin isoform 7
See identical proteins and their annotated locations for NP_861968.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) lacks two alternate in-frame exons in the 5' coding region and includes an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 7, also referred to as isoform delE2/3) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC004882, AF369657, AF369665
- Consensus CDS
-
CCDS13865.1
- Related
- ENSP00000340626.4, ENST00000353887.8
- Conserved Domains (5) summary
-
- PLN03086
Location:224 → 284
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:37 → 139
- B41; Band 4.1 homologues
- cd13194
Location:133 → 229
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:264 → 496
- ERM; Ezrin/radixin/moesin family
- cl28922
Location:20 → 41
- Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
-
NM_181831.3 → NP_861969.1 merlin isoform 7
See identical proteins and their annotated locations for NP_861969.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (13) lacks two alternate in-frame exons in the 5' coding region and differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 7, also referred to as isoform delE2/3) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC004882, AF369657, BC003112
- Consensus CDS
-
CCDS13865.1
- Related
- ENSP00000335652.7, ENST00000334961.11
- Conserved Domains (5) summary
-
- PLN03086
Location:224 → 284
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:37 → 139
- B41; Band 4.1 homologues
- cd13194
Location:133 → 229
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:264 → 496
- ERM; Ezrin/radixin/moesin family
- cl28922
Location:20 → 41
- Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
-
NM_181832.3 → NP_861970.1 merlin isoform 2
See identical proteins and their annotated locations for NP_861970.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2), one of the two predominant isoforms, has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC004882, AF369668, CF138178, CN419318
- Consensus CDS
-
CCDS13862.1
- UniProtKB/TrEMBL
-
B7Z4B6
- Related
- ENSP00000380891.3, ENST00000397789.3
- Conserved Domains (4) summary
-
- PLN03086
Location:307 → 367
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:23 → 222
- B41; Band 4.1 homologues
- cd13194
Location:216 → 312
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:347 → 579
- ERM; Ezrin/radixin/moesin family
-
NM_181833.3 → NP_861971.1 merlin isoform 8
See identical proteins and their annotated locations for NP_861971.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) lacks several alternate in-frame exons, compared to variant 1. The resulting protein (isoform 8, also referred to as isoform Mer162) is shorter than isoform 1.
- Source sequence(s)
-
AC004882, AF122827, CF138178, CN419318
- Consensus CDS
-
CCDS54516.1
- UniProtKB/Swiss-Prot
-
P35240
- Related
- ENSP00000409921.2, ENST00000413209.6
- Conserved Domains (2) summary
-
- cd17186
Location:20 → 103
- FERM_F1_Merlin; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in merlin and similar proteins
- pfam00373
Location:109 → 148
- FERM_M; FERM central domain
RNA
-
NR_176267.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC004882, AC005529
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
29603556..29698600
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047441386.1 → XP_047297342.1 merlin isoform X2
- UniProtKB/TrEMBL
-
B7Z4B6
-
XM_017028809.3 → XP_016884298.1 merlin isoform X1
- UniProtKB/TrEMBL
-
B7Z4B6
- Conserved Domains (4) summary
-
- PLN03086
Location:269 → 329
- PLN03086; PRLI-interacting factor K; Provisional
- smart00295
Location:1 → 184
- B41; Band 4.1 homologues
- cd13194
Location:178 → 274
- FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
- pfam00769
Location:308 → 557
- ERM; Ezrin/radixin/moesin family
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
30066918..30161963
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054325658.1 → XP_054181633.1 merlin isoform X2
- UniProtKB/TrEMBL
-
B7Z4B6
-
XM_054325657.1 → XP_054181632.1 merlin isoform X1
- UniProtKB/TrEMBL
-
B7Z4B6
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_181826.1: Suppressed sequence
- Description
- NM_181826.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
-
NM_181827.1: Suppressed sequence
- Description
- NM_181827.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
-
NM_181834.1: Suppressed sequence
- Description
- NM_181834.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
-
NM_181835.1: Suppressed sequence
- Description
- NM_181835.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.