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    RAP2B RAP2B, member of RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5912, updated on 9-Dec-2024

    Summary

    Official Symbol
    RAP2Bprovided by HGNC
    Official Full Name
    RAP2B, member of RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9862
    See related
    Ensembl:ENSG00000181467 MIM:179541; AllianceGenome:HGNC:9862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See RAP2B in Genome Data Viewer
    Location:
    3q25.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (153162226..153170627)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (155932795..155941196)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (152880015..152888416)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:152855858-152857057 Neighboring gene KIAA1328 pseudogene 1 Neighboring gene uncharacterized LOC124909451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:152877821-152878352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:152878353-152878882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:152879114-152879682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14831 Neighboring gene uncharacterized LOC105374164 Neighboring gene RNA, 7SL, cytoplasmic 300, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr3:152943874-152944499 Neighboring gene MPRA-validated peak4867 silencer Neighboring gene Sharpr-MPRA regulatory region 1900 Neighboring gene Sharpr-MPRA regulatory region 4515 Neighboring gene long intergenic non-protein coding RNA 3109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20717 Neighboring gene long intergenic non-protein coding RNA 2006

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC20484

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in establishment of endothelial intestinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet aggregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rap-2b
    Names
    small GTP binding protein
    NP_002877.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002886.4NP_002877.2  ras-related protein Rap-2b

      See identical proteins and their annotated locations for NP_002877.2

      Status: REVIEWED

      Source sequence(s)
      AC117394, AI718675, AW997098, BC012362, BI551390, BQ378964, BU507815, BU860799, BX116683, CB116910, HY071303
      Consensus CDS
      CCDS3170.1
      UniProtKB/Swiss-Prot
      P17964, P61225, Q96EG5, Q9CXG0
      UniProtKB/TrEMBL
      Q5JQ44
      Related
      ENSP00000319096.2, ENST00000323534.5
      Conserved Domains (1) summary
      cd04176
      Location:3165
      Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      153162226..153170627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      155932795..155941196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)