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    TNP2 transition protein 2 [ Homo sapiens (human) ]

    Gene ID: 7142, updated on 9-Dec-2024

    Summary

    Official Symbol
    TNP2provided by HGNC
    Official Full Name
    transition protein 2provided by HGNC
    Primary source
    HGNC:HGNC:11952
    See related
    Ensembl:ENSG00000178279 MIM:190232; AllianceGenome:HGNC:11952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TP2
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including penetration of zona pellucida; positive regulation of protein processing; and sperm DNA condensation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in male germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 12.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TNP2 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11267857..11269325, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11304079..11305547, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11361714..11363182, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371082 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11344039-11344246 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7197 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11359883-11360383 Neighboring gene suppressor of cytokine signaling 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11365871-11366567 Neighboring gene uncharacterized LOC124900380 Neighboring gene protamine 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of transition protein 2 (during histone to protamine replacement) (TNP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116783, MGC116785

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in penetration of zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sperm DNA condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nuclear transition protein 2
    Names
    TP-2
    transition protein 2 (during histone to protamine replacement)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005425.5NP_005416.1  nuclear transition protein 2

      See identical proteins and their annotated locations for NP_005416.1

      Status: VALIDATED

      Source sequence(s)
      AC009121, AI220577, BX282422, X63758
      Consensus CDS
      CCDS45410.1
      UniProtKB/Swiss-Prot
      Q05952, Q9NZB0
      UniProtKB/TrEMBL
      A0A2R8Y7P0, Q4VB56
      Related
      ENSP00000325738.3, ENST00000312693.4
      Conserved Domains (1) summary
      pfam01254
      Location:1134
      TP2; Nuclear transition protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11267857..11269325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11304079..11305547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)