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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_012105.5 → NP_036237.2 beta-secretase 2 isoform A preproprotein
See identical proteins and their annotated locations for NP_036237.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (A).
- Source sequence(s)
-
AF178532, AF188276, AF200342, AL773578
- Consensus CDS
-
CCDS13668.1
- UniProtKB/Swiss-Prot
- A8K7P1, Q5DIH8, Q8N2D4, Q9H2V8, Q9NZL1, Q9NZL2, Q9UJT6, Q9Y5Z0
- Related
- ENSP00000332979.6, ENST00000330333.11
- Conserved Domains (2) summary
-
- cd05473
Location:89 → 450
- beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
- pfam00026
Location:92 → 430
- Asp; Eukaryotic aspartyl protease
-
NM_138991.3 → NP_620476.1 beta-secretase 2 isoform C preproprotein
See identical proteins and their annotated locations for NP_620476.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (c) lacks an alternate in-frame exon, compared to variant a. The encoded isoform (C) is shorter than isoform A.
- Source sequence(s)
-
AF188276, AF200342, AL773578
- Consensus CDS
-
CCDS13669.1
- UniProtKB/Swiss-Prot
-
Q9Y5Z0
- Related
- ENSP00000327528.4, ENST00000347667.5
- Conserved Domains (2) summary
-
- pfam00026
Location:92 → 380
- Asp; Eukaryotic aspartyl protease
- cl11403
Location:89 → 400
- pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
-
NM_138992.3 → NP_620477.1 beta-secretase 2 isoform B preproprotein
See identical proteins and their annotated locations for NP_620477.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (b) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant a. The encoded isoform (B) is shorter and has a distinct C-terminus, compared to isoform A.
- Source sequence(s)
-
AF188276, AF188277, AF200342, AL773578
- Consensus CDS
-
CCDS13670.1
- UniProtKB/Swiss-Prot
-
Q9Y5Z0
- Related
- ENSP00000333854.6, ENST00000328735.10
- Conserved Domains (1) summary
-
- cl11403
Location:89 → 393
- pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000021.9 Reference GRCh38.p14 Primary Assembly
- Range
-
41168160..41282530
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017028314.2 → XP_016883803.1 beta-secretase 2 isoform X1
- UniProtKB/TrEMBL
-
B3KNE8
Alternate T2T-CHM13v2.0
Genomic
-
NC_060945.1 Alternate T2T-CHM13v2.0
- Range
-
39556492..39670904
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054324423.1 → XP_054180398.1 beta-secretase 2 isoform X1
- UniProtKB/TrEMBL
-
B3KNE8
-
XM_054324424.1 → XP_054180399.1 beta-secretase 2 isoform X2
- UniProtKB/TrEMBL
-
B3KNE8